人才队伍
吴信
吴信，1979年生，中共党员，研究员，博士，博士生导师，中国科学院天津工业生物技术研究所研究员、营养资源合成生物学研究组PI。2010年毕业于中国科学院大学获得博士学位，在中国科学院亚热带农业生态所先后任创新助理研究员、副研究员和研究员；先后在法国国家农业科学研究院（INRA）和荷兰伊拉斯姆大学医学院访学；2021年至今在中国科学院天津工业生物技术研究所研究员。入选国家科技创新领军人才、国家创新人才推进计划中青年科技创新领军人才等。
围绕微生物与营养资源开发及其在饲用和食品行业的应用，主持国家重点研发专项课题、省部级科技创新项目等10多个项目，授权发明专利53项，在Bioresource Technology、Microbiome、Food & Function、Animal Nutrition等国内外期刊上发表论文200多篇；以前三完成人获国家自然科学奖二等奖、中国科学院科技促进发展奖、中华农业科技奖和省发明奖一等奖等省部级奖8项。主要社会兼职：中国农学会理事、微量元素与食物链分会秘书长等。
1. 利用合成生物学的理念与技术，开展功能性营养物质生物合成的底层创新设计，研发一碳和生物质利用等多场景应用的微生物源蛋白和功能性营养资源开发与应用技术；
2. 基于人类和动物营养代谢及其生理功能，研发新型微生物蛋白、功能性肽、核苷酸及有机微量元素等营养物质生物合成与应用关键技术。
1. 国家科技进步奖二等奖（排名第二），2025年
2. 国家自然科学二等奖（第三），2016年
3. 湖南省技术发明奖一等奖（第二），2017年
4. 中国科学院科技促进发展奖（第二），2018年
5. 中华农业科技奖一等奖（第三），2015年
6. 中华农业科技奖创新团队奖（第四），2021年
7. 优秀研究生导师团队，省级，2018
8. 市优秀青年科技人才，市地级，2019
1. Yuanyuan Du, Changyu Pi, Kai Hong, Le Gao*, Xin Wu*. Cross-Kingdom Metabolic Engineering Paradigm Elevating Sustainable Protein Production. Advanced Science, 2026: e17703
2. Tiantian Zhou, Xinyi Chen, Yuehan Wang, Yuehan Wang, Xutao Zhang, Lingchao Miao, Rui Tian, Yumeng Li, Wai San Cheang*, Wu, Xin*. Amelioration of obesity-induced endothelial dysfunction by a synthetic ocean-derived peptide via regulating PPARα/γ pathway. Food Research International, 2026, 236: 119215
3. Changyu Pi, Jinyang Li, Fangting Jiang, Le Gao*, Xin Wu*. Closing Loop: Systems-Level Integration of Synthetic Consortia and Process Engineering for Lignocellulosic Microbial Lipid Biomanufacturing. Journal of Bioresources and Bioproducts, 2026: 100254
4. Le Gao*, Khoo Shing Ching, Zhaokun Zhang, Xin Wu*. Trends in Sustainable Production of Advanced Single-Cell Protein Manufacturing from Non-grain Feedstocks. Trends in Biotechnology, 2026, , 44(1): 65–78
5. Yumeng Li, Tongtong Bao, Lumin Gao, Xutong Tian, Junyu Xue, Caike Jin, Shujin Wang, Xin Wu*. Aging triggers an intestinal energy crisis and HDL3 deficiency disrupting gut–liver axis homeostasis. Aging Cell, 2026, 25(3): e70445
6. Feng Yingying, Jialu Wang, Jinyang Li, Zhaokun Zhang, Yuying Wu, Gao Le*, Xin Wu*. Biosynthesis and nutritional evaluation of iron-enriched Aspergillus oryzae as a novel iron supplement. Food Research International, 2026, 227:118259
7. Chia Hau Lee, Bemgba Bevan Nyakuma, Tiantian Zhou, Junyu Xue, Theng Ho Cheong, Yumeng Li, Syie Luing Wong, Le Gao, Xin Wu*. Dietary geroprotective peptides: Structural determinants, AI-driven discovery, and synthetic biology production for healthy ageing. Food Research International, 2026, 236: 119189
8. Lumin Gao, Xudong Yang, Shufan Liu, Lu Liu, Xiaofan Ma, Shuguang Liu, Xin Wu*. One-carbon-derived bioactive peptides improve reproductive performance via regulating placental nutrient transport and offspring glycolipid metabolism. npj Science of Food, 2026, 10: 120.
9. Gao Le, Tiantian Zhou, Jie Yuan, Shouchang Zhang, Kai Hong, Zhaokun Zhang, Lee Chia Hau, Wai San Cheang, Chichun Zhou*, Wu Xin*. AI-Powered De Novo Architecturing of Marine-Mimetic Antioxidant Peptides in Yeast Synbio Factories. Chemical Engineering Journal, 2025, 169604
10. Le Gao, Jie Yuan, Kai Hong, Xin Wu*. Advancing Pichia pastoris: A Next-Generation Platform for Sustainable Biomanufacturing. Biotechnology advances, 2025, 82(6):108593
11. Changyu Pi, Jinyang Li, Tongtong Bao, Le Gao*, Xin Wu*. Integrated Base Editing and Microfluidics Boost Microbial Lipid Production from Lignin. Bioresource Technology, 2025: 133441
13. Le Gao,Jie Yuan,Kai Hong,Xin Wu*. Advancing Pichia pastoris: A Next-Generation Platform for Sustainable Biomanufacturing. Biotechnology advances,2025,82(6):108593
14. Le Gao,Fangting Jiang,Zhaokun Zhang,Daochen Zhu,Xin Wu.Unlocking lignin valorization and harnessing lignin-based raw materials for bio-manufacturing. Science China. Life sciences,2025:DOI: 10.1007/s11427-024-2792-x
15. Jinyang Li,Fangting Jiang,Changyu Pi,Tongtong Bao,Le Gao,Xin Wu*. Multi-omic profiling of a novel Myrothecium species reveals its potential mechanism of lignin degradation. International Journal of Biological Macromolecules,2024: 282(Pt 5):137134
16. Le Gao#,Xiaolin Li,Yumeng Li,Zhaokun Zhang,Jialu Wang,Chao Xu,Wu Xin*. Biochemical characterization,biosynthesis mechanism,and functional evaluation of selenium-enriched aspergillus oryzae A02. International Journal of Biological Macromolecules,2024,275:133714
17. Yumeng Li,Xutong Tian,Juyue Luo,Tongtong Bao,Shujin Wang,Xin Wu*. Molecular mechanisms of aging and anti-aging strategies. Cell Communication and Signaling,2024,22(1):285
18. Jianying Yang,Juyue Luo,Xutong Tian,Yumeng Li*,Xin Wu*. Progress in Understanding Oxidative Stress,Aging,and Aging-Related Diseases,Antioxidants,2024,13(4):394
19. Yumeng Li,Tongtong Bao,Lumin Gao,Qian Yu,Xutong Tian,Haofan Dong,Ran Duan,Kaimin Niu,Jianying Yang,Shujin Wang,Xin Wu*. Alleviation of hepatic insulin resistance and steatosis with NMN via improvement in endoplasmic reticulum-mitochondria miscommunication in the liver of HFD mice. Biomedicine & Pharmacotherapy,2024,175: 116682
20. Yingying Feng,Yuying Wu,Jialu Wang,Zhenglin Dong,Qian Yu,Chunxue Liu,Haihua Wang,Xin Wu*. Enteromorpha prolifera polysaccharide-Fe (III) complex promotes intestinal development as a new iron supplement.SCIENCECHINA Life Sciences,2024:219-231
21. Yingying Feng,Teketay Wassie,Yuying Wu,Xin Wu*. Advances on novel iron saccharide-iron (III) complexes as nutritional supplements. Critical Reviews in Food Science and Nutrition,2024,DOI: 10.1080/10408398.2023.2222175
22. Yingying Feng,Renyou Gan,Wai San Cheang,Xin Wu*. Editorial: Immunometabolism and Nutritional Regulation of Intestinal Mucosal Immunity,2024,15:1365690
23. Gao L,Meng J,Wuling Dai,Zhaokun Zhang,Haofan Dong,Qianqian Yuan,Wuyuan Zhang,Liu SG,Wu Xin*. Deciphering cell wall sensors enabling the construction of robust P. pastoris for single-cell protein production. Biotechnology for Biofuels and Bioproducts,2023 DOI: 10.1186/s13068-023-02428-7
24. Meng Jiao,Liu Shufan,Gao Le,Hong Kai,Liu Shuguang,Wu Xin*. Economical production of Pichia pastoris single cell protein from methanol at industrial pilot scale. Microbial Cell Factories,2023,22: 198
25. Le Gao,Zhuohang Yu,Shengjie Wang,Yuejie Hou,Shouchang Zhang,Chichun Zhou*,Wu Xin*. A new paradigm in lignocellulolytic enzyme cocktail optimization: free from expert-level prior knowledge and experimental datasets. Bioresource Technology,2023,(388):29758
26. Yingying Feng,Teketay Wassie,Renyou Gan*,Xin Wu*. Structural Characteristics and Immunomodulatory Effects of Sulfated Polysaccharides Derived from Marine Algae. Critical Reviews in Food Science and Nutrition,2023,63: 7180–7196
27. Shujin Wang*,Wei Fu,Xueya Zhao,Xiaojiao Chang,Hujun Liu,Lin Zhou,Jian Li,Rui Cheng,Xin Wu*,Xi Li*,Changpo Sun*. Mycotoxin disturbs the reproductive-immune axis: the role of gut microbial metabolites. Microbiome,2022,10:234
28. Yin Jie,Yuying Li,Hui Han,Shuai Chen,Jing Gao,Gang Liu,Xin Wu*,Jinping Deng,Xingguo Huang,Rejun Fang,Tiejun Li*,Russel J. Reiter,Guoqiang Zhu,Wenkai Ren*,Yulong Yin. Melatonin improves lipid metabolism by reprograming gut microbiota and microbiota-derived acetic acid. Journal of Pineal Research,2018,65:e12524
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