第二十一期:Small molecules targeting immune receptor TREM2 in Alzheimer’s disease
报告嘉宾:
SONG Yuhua 美国阿拉巴马大学伯明翰分校生物医学工程系教授
报告时间:
2024-11-27
报告地点:
C408会议室
报告摘要:
Alzheimer’s disease (AD) is the leading cause of dementia worldwide and nearly 95% of all AD cases are late-onset AD. Immune receptor TREM2 plays an important role in modulating inflammatory responses in immune cells. Single amino acid variants in TREM2 have been identified by genome-wide association studies to be one of the strongest genetic risk factors for AD. Using integrated computational and experimental approaches, Dr. Yuhua Song research group is actively working to identify small molecules, including endogenous ligands and FDA-approved drugs repositioning, as TREM2 ligand to regulate TREM2-mediated immune activation, investigate co-operativity of TREM2 ligands for potential combined drug treatment, study the molecular basis of AD-associated variants in TREM2 on TREM2-ligand binding and function, and determine the small molecules able to compensate the loss of TREM2 function by AD-associated variants. Outcomes could have translational significance in the development of potential therapeutic strategies for Alzheimer’s disease treatment.