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【9月1日报告】Natural product biosynthesis: from cell-based to cell-free biosynthetic factories
  发布时间:2016-08-30    供稿部门:

  报告题目Natural product biosynthesis: from cell-based to cell-free  biosynthetic factories  

  报告人:李健  美国西北大学博士后   

  报告时间91日(周四) 9:30-10:30    

  报告地点:C408   

  报告摘要:Natural products originated from living organisms (e.g., microbes, plants and animals) are a large family of low molecular weight organic compounds, and possess diverse chemical structures and pharmaceutically relevant activities that act as significant sources for drug discovery and development. However, on the one hand, the native producers often suffer from low productivity and titers of interesting molecules that limits their clinical applications. On the other hand, the structural complexity of many compounds makes chemical synthesis hardly feasible. As alternative and potential approaches, I will show the feasible strategies of using 1) easy-to-handle surrogate microbes for heterologous production of NPs by recombinant expression of their entire gene cluster in appropriate hosts; 2) cell-free system for reconstruction of NPs biosynthesis directly from DNA through the cell-free protein synthesis technology.  

  报告人简介李健于20139月在德国柏林工业大学获得生物工程专业博士学位,随后在美国西北大学做博士后研究至今,主要从事生物工程、发酵工程及合成生物学等相关领域的研究工作,致力于大肠杆菌基因工程菌的构建和高密度液态发酵、非核糖体多肽类抗生素的异源微生物生产、以及开发无细胞生物合成(Cell-free Synthetic Biology)技术来高效表达蛋白质和生产具有药用价值的天然产物。已在《ACS Synthetic Biology》、《Microbial Cell Factories》、《Applied Microbiology and Biotechnology》、《Journal of Biotechnology》和《 Biotechnology Journal》等本专业主流学术期刊上正式发表SCI论文15篇(其中第一作者论文10篇,通讯作者论文3篇,封面论文2篇),SCI论文他引200余次。   

     

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