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| 论文题目_中文 |
Biocatalytic asymmetric amination of carbonyl functional group —— A synthetic biology approach to organic chemistry |
| 第一作者: |
Dunming Zhu |
| 摘要: |
Transaminases catalyze amino transfer reactions from amino donors such as amino acids or amines to keto acids or ketones to afford chiral amino acid or amines in optically pure form. a-Amino acid dehydrogenases catalyze the asymmetric reductive amination of a-keto acids using ammonia as amino donor to furnish L-amino acids. The distinct features and synthetic application of these two enzymes are reviewed in an effort to illustrate their promising and challenging aspects in serving as approaches to the direct asymmetric synthesis of optically pure amines from the corresponding keto compounds, a formidable problem in organic chemistry.
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| 联系作者: |
Dunming Zhu |
| 页码: |
1420-1431 |
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| 发表年度: |
2009 |
| 卷: |
4 |
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| 刊物名称: |
Biotechnology Journal |
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| 论文类别: |
SCI |
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