H. Zhang, X. Chen, T. Lv, J. Feng, X. Liu, P. Yao, Q. Wu, D. Zhu, “Engineering a Carbonyl Reductase to Simultaneously Increase Activity toward Bulky Ketone and Isopropanol for Dynamic Kinetic Asymmetric Reduction via Enzymatic Hydrogen Transfer”, ACS Catalysis, 2023, 13, 9960–9968. https://doi.org/10.1021/acscatal.3c01569
2. Y. Liu, L. Zhu, Y. Cui, A. Roosta, J. Feng, X. Chen, P. Yao, Q. Wu, D. Zhu, “Photoredox/Enzymatic Catalysis Enabling Redox-Neutral Decarboxylative Asymmetric C–C Coupling for Asymmetric Synthesis of Chiral 1,2-Amino Alcohols”, JACS Au, 2023, https://doi.org/10.1021/jacsau.3c00366
3. T. Lv, J. Feng, X. Chen, Y. Luo, Q. Wu, D. Zhu, Y. Ma, “Creating novel amine dehydrogenases for precise synthesis of single stereoisomer of β-amino ketones with an all-carbon quaternary stereocenter via desymmetric reductive amination”, ACS Catalysis, 2023, 13, 5053-5061. https://doi.org/10.1021/acscatal.3c00226
4. Y. Li, N. Hu, Z. Xu, Y. Cui, J. Feng, P. Yao, Q. Wu, D. Zhu, Y. Ma “Asymmetric Synthesis of N-Substituted 1,2-Amino Alcohols via One-Pot Sequential Enzymatic Hydroxymethylation and Asymmetric Reductive Amination”, Angewandt Chemie, International Edition, 2022, 61, e202116344 https://doi.org/10.1002/anie.202116344
5. N. Liu, L. Wu, J. Feng, X. Sheng, J. Li, X. Chen, J. Li, W. Liu, J. Zhou, Q. Wu, D. Zhu, “Crystal Structures and Catalytic Mechanism of L-erythro-3,5-Diaminohexanoate Dehydrogenase and Rational Engineering for Asymmetric Synthesis of β-Amino Acids”, Angewandt Chemie, International Edition, 2021, 60, 10203–10210 https://doi.org/10.1002/anie.202017225.
6. P. Yao, J. R. Marshall, Z. Xu, J. Lim, S. J. Charnock, D. Zhu, N. J. Turner, “Asymmetric Synthesis of N-Substituted α-Amino Esters from α-Ketoesters via Imine Reductase-Catalyzed Reductive Amination”, Angewandt Chemie, International Edition, 2021, 60, 8717–8721 https://doi.org/10.1002/anie.202016589 .
7. S. Yu, J. Li, P. Yao, J. Feng, Y. Cui, J. Li, X. Liu, Q. Wu, J. Lin, D. Zhu, “Inverting the enantiopreference of nitrilase-catalyzed desymmetric hydrolysis of prochiral dinitriles by reshaping the binding pocket with a “mirror image” strategy”, Angewandt Chemie, International Edition, 2021, 60, 3679–3684. https://doi.org/10.1002/anie.202012243 (selected as Hot Paper).
8. J. Li, J. Feng, X. Chen, J. Gong, Y. Cui, H. Zhang, D. Bu, Q. Wu, D. Zhu, “Structure-Guided Directed Evolution of a Carbonyl Reductase Enables the Stereoselective Synthesis of (2S,3S)-2,2-Disubstituted-3-hydroxycyclopentanones via Desymmetric Reduction”, Organic Letters, 2020, 22, 3444-3448. https://dx.doi.org/10.1021/acs.orglett.0c00892
9. N. Liu, J. Feng, R. Zhang, X. Chen, X. Li, P. Yao, Q. Wu, Y. Ma, D. Zhu, “Efficient Microbial Synthesis of Key Steroidal Intermediates from Bio-Renewable Phytosterols by Genetically Modified Mycobacterium fortuitum Strains”, Green Chemistry, 2019, 21, 4076–4083. https://doi.org/10.1039/c9gc01267b
10. X. Chen, H. Zhang, M. A. Maria-Solano, W. Liu, J. Li, J. Feng, X. Liu, S. Osuna, R.-T. Guo, Q. Wu, D. Zhu, Y. Ma, “Efficient Reductive Desymmetrization of Bulky Prochiral 1,3-Cyclodiketone Enabled by Structure-Guided Directed Evolution of a Carbonyl Reductase”, Nature Catalysis, 2019, 2, 931-941. https://doi.org/10.1038/s41929-019-0347-y
11. Q. Chen, X. Chen, J. Feng, Q. Wu, D. Zhu, Y. Ma “Improving and inverting Cb-stereoselectivity of threonine aldolase via substrate-binding-guided mutagenesis and a stepwise visual screening”, ACS Catalysis, 2019, 9, 4462-4469. https://doi.org/10.1021/acscatal.9b00859
12. W. Lu, X. Chen, Y. Wang, J. Feng, Q. Wu, D. Zhu, “A Fungal P450 from Thanatephorus cucumeris with Novel Steroid Hydroxylation Capabilities”, Applied and Environmental Microbiology, 2018, 84: e00503-18. https://doi.org/10.1128/AEM.00503-18 (selected as Spotlight Article by Editors).
13. X. Chen, H. Zhang, J. Feng, Q. Wu, D. Zhu, “Molecular basis for the high activity and enantioselectivity of carbonyl reductase from Sporobolomyces salmonicolor toward α-halo-acetophenones”, ACS Catalysis, 2018, 8, 3525-3531. https://doi.org/10.1021/acscatal.8b00591
14. P. Yao, P. Cong, R. Gong, J. Li, G. Li, J. Ren, J. Feng, J. Lin, P. C. K. Lau, Q. Wu, D. Zhu, “Biocatalytic Route to Chiral 2-Substituted-1, 2, 3, 4-tetrahydroquinolines Using Cyclohexylamine Oxidase Muteins”, ACS Catalysis, 2018, 8, 1648-1652. https://doi.org/10.1021/acscatal.7b03552
15. J. Ren, P. Yao, S. Yu, W. Dong, Q. Chen, J. Feng, Q. Wu, D. Zhu, “An Unprecedented Effective Enzymatic Carboxylation of Phenols”, ACS Catalysis, 2016, 5, 564-567. https://doi.org/10.1021/acscatal.5b02529
16. D. Zhang, X. Chen, R. Zhang, P. Yao, Q. Wu, D. Zhu, “Development of β-Amino Acid Dehydrogenase for the Synthesis of β-Amino Acids via Reductive Amination of β-Keto Acids”, ACS Catalysis, 2015, 5, 2220-2224. https://doi.org/10.1021/cs5017358