2009.06-现在      中国科学院天津工业生物技术研究所研究员、博导

                  （2018.10 三级，2022.06 二级）

1992.07-2009.05   中国科学院成都生物研究所、成都地奥制药集团有限公司

任研究实习员、助研（1993年）、副研（1998年）、研究员（四级，2006年），期间2001年9月-2004年7月在四川大学华西医院医学遗传专业博士研究生，并获理学博士学位

1989.09-1992.06   四川大学生物系生物化学专业蛋白质化学方向研究生，获理学硕士学位

1986.08-1989.08   安徽淮北煤炭师范学院图书馆实习馆员

1982.09-1986.07   四川大学生物系生物化学专业本科，获理学学士学位

生物催化与绿色化工

1.国家重点研发计划合成生物学专项项目（2019YFA0905303）1项、课题负责人

2. 天津专项项目（2019年TSBICIP-KJGG-001）1项，项目负责人

3. 2020年度国家重点研发计划“绿色生物制造”重点专项子课题1项，子课题负责人

4. 企业合作项目多项，项目负责人

1. 2023年11月获2022年度浙江省科技进步奖一等奖（排名第4）

2. 2016年度天津市优秀共产党员称号

1. Liu Y, Zhu L, Li X, Cui Y, Roosta A, Feng J*, Chen X,Yao P, Wu Q*, Zhu D*(2023)Photoredox/Enzymatic Catalysis Enabling Redox-Neutral Decarboxylative Asymmetroc C-C Coupling for Asymmetric Synthesis of Chiral 1,2-Amino Alcohols.

JACS ^Au, https://doi.org/10.1021/jacsau.3c00366.

2. Xu Z, Feng J, Yao P, * Wu Q * and Zhu D*(2023)Chemo-enzymatic Synthesis of Chiral 3-substituted Tetrahydroquinolines by a Sequential Biocatalytic Cascade and Buchwald–Hartwig Cyclization. Green Chem., 25: 4667-4673, doi: 10.1039/d3gc00047h

3. Zhou C, Chen X,* Lv T, Han X, Feng J, Liu W, Wu Q,* Zhu D* (2023) Flipping the Substrate Creates a Highly Selective Halohydrin Dehalogenase for the Synthesis of Chiral 4‑Aryl-2-oxazolidinones from Readily Available Epoxides. ACS Catal.,13: 4768-77 doi.org/10.1021

/acscatal.2c06417

4. Feng J, Wu Q, Zhu D*, Ma Y (2022) Biotransformation Enables Innovations Toward Green Synthesis of Steroidal Pharmaceuticals. ChemSusChem, e202102399 doi:10.1002/cssc.202102399

5. Wang Y, Zhang R, Feng J, Wu Q*, Zhu D*, Ma Y (2022) A New 3-Ketosteroid-Delta(1)-Dehydrogenase with High Activity and Broad Substrate Scope for Efficient Transformation of Hydrocortisone at High Substrate Concentration. Microorganisms, 10(3) doi:10.3390/microorganisms10030508

6. Li Y, Hu N, Xu Z, Cui Y, Feng J, Yao P*, Wu Q*, Zhu D*, Ma Y (2022) Asymmetric Synthesis of N-Substituted 1,2-Amino Alcohols from Simple Aldehydes and Amines by One-Pot Sequential Enzymatic Hydroxymethylation and Asymmetric Reductive Amination.  Angew. Chem. Int. Ed., 61(17): e202116344 doi:10.1002/anie.202116344

7. Liu N, Wu L, Feng J, Sheng X, Li J, Chen X, Li J, Liu W, Zhou J*, Wu Q*, Zhu D* (2021) Crystal Structures and Catalytic Mechanism of l-erythro-3,5-Diaminohexanoate Dehydrogenase and Rational Engineering for Asymmetric Synthesis of beta-Amino Acids. Angew. Chem. Int. Ed., 60: 10203-10210 doi:10.1002/anie.202017225

8. Yu S, Li J, Yao P, Feng J, Cui Y, Li J, Liu X, Wu Q*, Lin J*, Zhu D* (2021) Inverting the Enantiopreference of Nitrilase-Catalyzed Desymmetric Hydrolysis of Prochiral Dinitriles by Reshaping the Binding Pocket with a Mirror-Image Strategy. Angew. Chem. Int. Ed. 60(7): 3679-3684 doi:10.1002/anie.202012243

9. Xu Z, Yao P, Sheng X, Li J, Li J, Yu S, Feng J, Wu Q*, Zhu D* (2020) Biocatalytic Access to 1,4-Diazepanes via Imine Reductase-Catalyzed Intramolecular Asymmetric Reductive Amination. ACS Catal., 10(15): 8780-8787 doi:10.1021/acscatal.0c02400

10. Chen X, Zhang H, Maria-Solano MA, Liu W, Li J, Feng J, Liu X, Osuna S*, Guo R-T, Wu Q*, Zhu D*, Ma Y (2019) Efficient Reductive Desymmetrization of Bulky 1,3-cyclodiketones Enabled by Structure-guided Directed Evolution of a Carbonyl Reductase. Nat. Catal., 2(10): 931-941 doi:10.1038/s41929-019-0347-y5

11. Liu N, Feng J, Zhang R, Chen X, Li X, Yao P, Wu Q*, Ma Y, Zhu D* (2019) Efficient microbial synthesis of key steroidal intermediates from bio-renewable phytosterols by genetically modified Mycobacterium fortuitum strains. Green Chem., 21(15): 4076-4083 doi:10.1039/c9gc01267b