2024.03 -  今      中国科学院天津工业生物技术研究所 研究员 

2022.08 -  2024.03 中国科学院天津工业生物技术研究所 副研究员

2018.12 – 2021.05 德国波恩大学， 博士后

2018.02 – 2022.06 江西省科学院微生物研究所， 助理研究员

2014.09 – 2017.12 武汉大学， 博士学习

2012.08 – 2014.05 浙江永宁药业股份有限公司， 实验员

2005.09 – 2012.06 湖北中医药大学，本科、 硕士学习

主要研究方向为天然产物发现与生物合成，主要致力于挖掘新的萜类合成酶,并综合运用化学生物学、结构生物学、同位素示踪等技术解析萜类合成酶的催化机制，同时结合化学修饰及途径重编程等策略制备新的萜类化合物。

主持国家自然科学基金青年基金一项和合成生物学海河实验室颠覆性创新项目一项

[1]A. Hou*, B. Li, Z. Deng, M. Xu*, J. S. Dickschat*, Cladosporin, A Highly Potent Antimalaria Drug?, ChemBioChem 2023, e202300154.

[2] A. Hou, J. S. Dickschat, Labelling studies in the biosynthesis of polyketides and non-ribosomal peptides, Natural Product Reports 2023.

[3] H. Tao^#, L. Lauterbach^#, G. Bian^#, R. Chen^#, A. Hou^#, T. Mori^#, S. Cheng, B. Hu, L. Lu, X. Mu, et al., Discovery of non-squalene triterpenes, Nature 2022, 606, 414-419.

[4] Z. Quan, A. Hou, B. Goldfuss, J. S. Dickschat, Mechanism of the bifunctional multiple product sesterterpene synthase AcAS from Aspergillus calidoustus, Angewandte Chemie International Edition 2022, 61, e202117273.

[5] L. Lauterbach^#, A. Hou^#, J. S. Dickschat, Rerouting and Improving Dauc‐8‐en‐11‐ol Synthase from Streptomyces venezuelae to a High Yielding Biocatalyst, Chemistry–A European Journal 2021, 27, 7923-7929.

[6] A. Hou, B. Goldfuss, J. S. Dickschat, Functional Switch and Ethyl Group Formation in the Bacterial Polytrichastrene Synthase from Chryseobacterium polytrichastri, Angewandte Chemie International Edition 2021, 60, 20781-20785.

[7] A. Hou, J. S. Dickschat, The EI‐MS Fragmentation Mechanisms of the Bacterial Diterpenes Polytrichastrene A and Wanju‐2, 5‐diene, European Journal of Organic Chemistry 2021, 2021, 6417-6423.

[8] A. Hou, J. S. Dickschat, Targeting active site residues and structural anchoring positions in terpene synthases, Beilstein Journal of Organic Chemistry 2021, 17, 2441-2449.

[9] A. Hou, J. S. Dickschat, Using Terpene Synthase Plasticity in Catalysis: On the Enzymatic Conversion of Synthetic Farnesyl Diphosphate Analogues, Chemistry–A European Journal 2021, 27, 15644-15649.

[10]    Y. Duan^#, M. Toplak^#, A. Hou^#, N. L. Brock, J. S. Dickschat, R. Teufel, A flavoprotein dioxygenase steers bacterial tropone biosynthesis via coenzyme A-ester oxygenolysis and ring epoxidation, Journal of the American Chemical Society 2021, 143, 10413-10421.

[11]     A. Hou, L. Lauterbach, J. S. Dickschat, Enzymatic synthesis of methylated terpene analogues using the plasticity of bacterial terpene synthases, Chemistry–A European Journal 2020, 26, 2178-2182.

[12]     A. Hou, J. S. Dickschat, The biosynthetic gene cluster for sestermobaraenes—discovery of a geranylfarnesyl diphosphate synthase and a multiproduct sesterterpene synthase from Streptomyces mobaraensis, Angewandte Chemie International Edition 2020, 59, 19961-19965.

[13]     A. Hou, J. S. Dickschat, On the mass spectrometric fragmentations of the bacterial sesterterpenes sestermobaraenes A–C, Beilstein Journal of Organic Chemistry 2020, 16, 2807-2819.

[14]     G. Bian^#, A. Hou^#, Y. Yuan, B. Hu, S. Cheng, Z. Ye, Y. Di, Z. Deng, T. Liu, Metabolic engineering-based rapid characterization of a sesquiterpene cyclase and the skeletons of fusariumdiene and fusagramineol from Fusarium graminearum, Organic letters 2018, 20, 1626-1629.

[15]     G. Bian, Y. Han, A. Hou, Y. Yuan, X. Liu, Z. Deng, T. Liu, Releasing the potential power of terpene synthases by a robust precursor supply platform, Metabolic Engineering 2017, 42, 1-8.

[16]     A. Hou, Z. Deng, H. Ma, T. Liu, Substrate screening of amino transaminase for the synthesis of a sitagliptin intermediate, Tetrahedron 2016, 72, 4660-4664.