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  研究员
 
姓名  
崔成森
性别  
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职称  
研究员
学历  
博士研究生
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电子邮件  
cuichs@tib.cas.cn
地址  
天津市空港经济区西七道32号
邮编  
300308

简历

2022-至今, 中国科学院天津工业生物技术研究所,研究员

2018-2021年,美国普渡大学化学与癌症研究中心,博士后

2017-2018年,美国哈佛大学化学与化学生物学系,博士后

2015-2017年,香港科技大学化学系,助理研究员

2011-2015年,英国布里斯托大学,博士

2007-2011年,西北农林科技大学,学士


研究方向:
  

主要研究方向为挖掘并改造天然产物生物合成途径中的酶分子,通过理性设计赋予其高转化率、高区域和立体选择性。开发以人工酶介导的新颖酶促反应,发展化学-酶法药物分子的绿色、可持续、高效的合成新路线,并积极推进产业化。


承担科研项目情况:
  

主持天津市合成生物技术创新能力提升行动项目。并以核心骨干身份参与了中国科学院先导专项项目。


获奖及荣誉:
  

天津市青年英才


代表论著:

参与合成的目标分子

18. Shen, Q.; Yan, J.; Zhang, Z.; Li, H.; Kong, D.; Han, X.; Shi, J.;Cui, C.;* Zhang, W.* Peroxygenase-catalyzed kinetic resolution of racemic hydroperoxides.Manuscript submitted.

17.  Li, H.; Duan, P.; Huang, Y.; Cui, C.; Hollmann, F.; Ma, Y.; Wang, Y.; Zhang, W. * Chemoenzymatic Valorisation of Lignin-Derived Phenols and Phenolic Acids. ACS Catal., 2023, Under review.

16.  Cui, C.; Dai, M.* Total Synthesis of UCS1025A via Tandem Carbonylative Stills Cross Coupling and Diels-Alder Reaction. Chin. J. Chem. 2023, 41, 3019-3024. (Invited contribution dedicated to the Special Issue of C1 Chemistry).

15.  Zhu, F.;‡ Zhang, J.;‡ Ma, Y.; Yang, L.; Gao, Q.; Gao, S.-S.;* Cui, C.* Semi-rational design of an imine reductase for asymmetric synthesis of alkylated S-4-azepanamines. Org. Biomol. Chem., 2023, 21, 4181-4184.

14.  Zhang, J.;‡ Ma, Y.;‡ Zhu, F.;‡ Bao, J.; Gao, S.-S.; * Cui, C.* Structure-guide rational design of an imine reductase for enantio-complementary synthesis of pyrrolidinamine. Chem. Sci., 2023, 14, 4265-4272.

Featured as an Outside Cover; Highlighted by TIB news.

13.  Ma, Y.; Yan, J.; Yang, L.; Yao, Y.; Wang, L.;* Gao, S.-S.;* Cui, C.* A Hybrid System for the Overproduction of Complex Ergot Alkaloid Chanoclavine. Front. Bioeng. Biotechnol., 2022, 10, 2386.

12.  Li, J.; Qu, G.; Li, X.; Tian, Y.; Cui, C.; Zhang, F.; Zhang, W.; Ma, J.;* Reetz, M.;* Sun, Z.* Rational enzyme design for enabling biocatalytic Baldwin cyclization and asymmetric synthesis of chiral heterocycles. Nat. Commun., 2022, 13, 7813.

11.   Zhang, J.; Li, X.; Chen, R.; Tan, X.; Liu, X.; Ma, Y.; Zhu, F.; An, C.; Wei, G.; Yao, Y.; Yang, L.; Zhang, P.; Wu, Q.; Sun, Z.; Wang, B.-G.;* Gao, S.-S.;* Cui, C.* Actinomycetes-derived imine reductases with a preference towards bulky amine substrates. Commun. Chem., 2022, 5, 123.

10.  Yu, Z.-P.; An, C.; Yao, Y.; Wang, C.-Y.; Sun, Z.; Cui, C.; Liu, L.;* Gao, S-S* A combined strategy for the overproduction of complex ergot alkaloid agroclavine. Synthetic and Systems Biotechnology, 2022, 7, 1126-1132.

9. Zhang, J.; Liao, D.; Chen, R.; Zhu, F.; Ma, Y.; Gao, L.; Qu, G.; Cui, C.; Sun, Z.;* Lei, X.;* Gao, S.* Tuning Imine Reductase for Asymmetric Synthesis of Azacycloalkylamines by Concise Structure-Guided Engineering. Angew. Chem. Int. Ed., 2022, e202201908.

8. Li, H.; Younes, S. H. H.; Chen, S.; Duan, P.;* Cui, C.; Ron Wever, R.; Zhang, W.;* Hollmann, F.;* A chemoenzymatic Hunsdiecker-type decarboxylative bromination of cinnamic acids. ACS Catal., 2022, 12, 4554-4559.

7. Cui, C.;‡ Dwyer, B. G.;‡ Liu, C.; Abegg, D.; Yin, X.; Hoch, D.; Cai, Z.; Qiu, N.; Liu, J.; Adibekian, A.; Dai, M.* Total synthesis and chemoproteomics connect curcusone diterpenes with oncogenic protein BRAT 1. J. Am. Chem Soc., 2021, 143, 4379-4386.

Featured in Purdue News, ScienceDaily, NSF Research News, and others; Highlighted by X-MOL and Synfacts.

6. Wang, Y.;‡ Cui, C.;‡ Dai, M.* Flow Chemistry-Enabled Divergent and Enantioselective Total Syntheses of Massarinolin A, Purpurolides B, D, E, 2,3-Deoxypurpurolide C, and Structural Revision of Massarinolin A. Angew. Chem. Int. Ed., 2021, 60, 24828-24832.

Selected as a Hot Paper; Featured as an Inside Cover; Highlighted by WileyChem

5. H. Raffa, N.; Won, T. H.; Sukowaty, A.; Candor, K.; Cui, C.; Halder, S.; Dai, M.;* Figueroa, J. A. L.; Schroeder, F. C.; Keller, N. P.* Dual-purpose isocyanides produced by Aspergillus fumigatus contribute to cellular copper suffiency and exhibit antimicrobial activity. Proc. Natl. Acad. Sci., USA, 2021, 118, e2015224118.

4. Cui, C.; Dai, W.-M.* Total synthesis of laingolide B stereoisomers and assignment of absolute configuration. Org. Lett., 2018, 20, 3358-3361.

3. Thistlethwaite, I. R. G.; Bull, F. M.; Cui, C.; Walker, P. D.; Gao S.-S.; Wang, L.; Song Z.; Masschelein, J.; Lavigne, R.; Crump, M. P.; Race, P. R.; Simpson, T. J.; and Wills, C. L.* Elucidation of the relative and absolute stereochemistry of the Kalimantacin/batumin antioiotics. Chem. Sci., 2017, 8, 6196-6201.

2. Shi, J.; Wu, J.; Cui, C.; Dai, W.-M.* Microwave-Assisted intramolecular Ullmann diaryl etherification as the Post-Ugi annulation for generation of dibenz[b,f][1,4]oxazepine scaffold. J. Org. Chem., 2016, 81, 10392-10403.

1. Zhang, J.*; Cui, C.; Chen, H.; Liu, J. The completion of esterification of free fatty acids in Zanthoxylum bungeanum seed oil with ethanol. International Journal of Green Energy, 2014, 11, 822-832.

申请或授权专利:

1. Dai, M.; Cui, C.; Cai, Z.; Adibekian, A., Dwyer, B. G. Curcusone diterpenoids and uses thereof. US20230250042A1.

2. 高书山; 张军; 崔成森; 马亚卿; 朱芳芳,还原胺化酶突变体及其在烷基化吡咯烷手性胺合成中的应用, CN202310233977.7.