人才队伍
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  研究员
 
姓名  
张武元
性别  
专家类别  
N/A
职称  
研究员
学历  
博士研究生
电话  
022-84866462
传真  
N/A
电子邮件  
zhangwy@tib.cas.cn
地址  
天津市空港经济区西七道32号
邮编  
300308

简历

2020.12- 中国科学院天津工业生物技术研究所,研究员、博导

2019.09-2020.11 西安交通大学,研究员、博导

2015.10-2019.07 荷兰代尔夫特理工大学,博士后研究员

2012.08-2016.07 荷兰代尔夫特理工大学,生物技术,博士

2009.09-2012.07 海南大学,应用化学,硕士

2005.09-2009.07 海南大学,应用化学,学士


研究方向:
  

围绕生物催化与生物转化,开展酶智能设计改造及其高效异源表达、发展新型酶催化理论与技术方法。并结合光化学催化等绿色催化技术,发展新型化-酶催化模式,开发具有产业应用潜力的新型生物合成途径,应用于有机合成、医药化学品合成、生物资源高值化等领域。


承担科研项目情况:
  

国家重点研发计划,2023-2027,主持

国家自然科学基金面上项目,2022-2025,主持

天津市合成生物技术创新能力提升行动,2021-2024,主持

企业横向项目3项,2022-2026,主持


获奖及荣誉:
  

天津市优秀青年科技工作者,2023

国家海外高层次人才计划,2023

中国科学院人才计划,2021


代表论著:

1. Shen,Q.;Yan,J.;Han,Y.;Zhang,Z.*;Li,H.;Kong,D.;Shi,J.;Cui,C.*;Zhang,W.*,Peroxygenase Enabled Reductive Kinetic Resolution for the Enantioenrichment of Organoperoxides. Angew. Chem. Int. Ed.2024, e202401590.

2. Li,H.;Duan,P.*;Huang,Y.;Cui,C.;Hollmann,F.*;Ma,Y.;Wang,Y.;Zhang,J.;Liu,W.;Zhang*,W.,Vanadium-Containing Chloroperoxidase-Catalyzed Versatile Valorization of Phenols and Phenolic Acids. ACS Catalysis2024,14 (3),1733-1740.

3. Han,X.#;Chen,F.#;Li,H.;Ge,R.;Shen,Q.;Duan,P.*;Sheng,X.*;Zhang,W.*,Reaction engineering blocks ether cleavage for synthesizing chiral cyclic hemiacetals catalyzed by unspecific peroxygenase. Nature Communications2024,15 (1),1235.

4. Zhang,Y.;Zhou,X.;Cui,J.;Huang,Y.;Liu,X.;Zhang,Y.;Chen,B.;Zhang,W.*,Peroxygenase-catalysed selective and scalable synthesis of 25-hydroxy-grundmann's ketone and its derivatives. Molecular Catalysis2023,547,113389.

5. Li,Z.;Ge,R.;Tan,L.;Zhang,W.*;Zhang,Y.*,Photodecarboxylase Displayed on Microbial Cell-Surface for Enhanced Biocatalytic Performance. ChemCatChem2023, e202300494.

6. Li,H.;Zhang,Y.;Huang,Y.;Duan,P.;Ge,R.;Han,X.;Zhang,W.,A Simple Access to gamma- and epsilon-Keto Arenes via Enzymatic Divergent C horizontal line H Bond Oxyfunctionalization. Advanced Science2023,10 (34),e2304605.

7. Li,F.;Xia,A.*;Guo,X.;Huang,Y.;Zhu,X.;Zhang,W.*;Chen,R.;Liao,Q.,Photo-driven enzymatic decarboxylation of fatty acids for bio-aviation fuels production in a continuous microfluidic reactor. Renewable and Sustainable Energy Reviews2023,183,113507.

8. Huang,Y.;Li,H.;Zhang,P.;Zhang,Y.;Duan,P.;Zhang,W.*,H2O2-driven enzymatic oxyfunctionalization of tertiary C–H bonds. Chemical Communications2023,59 (60),9219-9222.

9. Gomez de Santos,P.;González-Benjumea,A.;Fernandez-Garcia,A.;Aranda,C.;Wu,Y.;But,A.;Molina-Espeja,P.;Maté,D. M.;Gonzalez-Perez,D.;Zhang,W.;Kiebist,J.;Scheibner,K.;Hofrichter,M.;Świderek,K.;Moliner,V.;Sanz-Aparicio,J.;Hollmann,F.;Gutiérrez,A.;Alcalde,M.,Engineering a Highly Regioselective Fungal Peroxygenase for the Synthesis of Hydroxy Fatty Acids. Angew. Chem. Int. Ed.2023,62 (9),e202217372.

10 Li,H.;Younes,S. H. H.;Chen,S.;Duan,P.*;Cui,C.;Wever,R.;Zhang,W.*;Hollmann,F.*,Chemoenzymatic Hunsdiecker-Type Decarboxylative Bromination of Cinnamic Acids. ACS Catalysis 2022,12 (8),4554-4559.

11. Wang,P.;Han,X.;Liu,X.*;Lin,R.;Chen,Y.;Sun,Z.*;Zhang,W.*,Synthesis of Enantioenriched Sulfoxides by an Oxidation-Reduction Enzymatic Cascade. Chemistry-A European Journal2022,28 (61),e202201997.

12. Shen,Q. Q.;Zhang,C.;Chen,L.;Huang,B. Q.;Yu,Y. S.;Zhang,Z. X.*;Zhang,W. Y.*,Characterization of Pt/g-C3N4-Catalyzed Methanol Oxidation to Drive Peroxygenase-Catalyzed Oxyfunctionalization of Hydrocarbons. ACS Sustainable Chemistry & Engineering2022,10,12156−12164.

13. Sang,X.;Tong,F.;Zeng,Z.*;Wu,M.;Yuan,B.;Sun,Z.;Sheng,X.;Qu,G.;Alcalde,M.;Hollmann,F.*;Zhang,W.*,A Biocatalytic Platform for the Synthesis of Enantiopure Propargylic Alcohols and Amines. Organic Letters 2022,24 (23),4252-4257.

14. Guo,X.;Xia,A.*;Li,F.;Huang,Y.;Zhu,X.;Zhang,W.*;Zhu,X.;Liao,Q.,Photoenzymatic decarboxylation to produce renewable hydrocarbon fuels: A comparison between whole-cell and broken-cell biocatalysts. Energy Conversion and Management2022,255,115311.

15. Chen,B.-S.;Zeng,Y.-Y.;Liu,L.;Chen,L.;Duan,P.;Luque,R.*;Ge,R.;Zhang,W.*,Advances in catalytic decarboxylation of bioderived fatty acids to diesel-range alkanes. Renewable and Sustainable Energy Reviews2022,158,112178.

16. Zhang,W.*;Li,H.;Younes,S. H. H.;Gomez de Santos,P.;Tieves,F.;Grogan,G.;Pabst,M.;Alcalde,M.;Whitwood,A. C.;Hollmann,F.*,Biocatalytic Aromaticity-Breaking Epoxidation of Naphthalene and Nucleophilic Ring-Opening Reactions. ACS Catalysis2021,11 (5),2644-2649.

17. Lin,R.;Deng,C.*;Zhang,W.*;Hollmann,F.;Murphy,J. D.*,Production of Bio-alkanes from Biomass and CO2. Trends in Biotechnology2021,39 (4),370-380.

18. Li,Y.;Yuan,B.;Sun,Z.;Zhang,W.*,C–H bond functionalization reactions enabled by photobiocatalytic cascades. Green Synthesis and Catalysis2021,2 (3),267-274.

19. Alagumalai,A.;Mahian,O.*;Hollmann,F.;Zhang,W.*,Environmentally benign solid catalysts for sustainable biodiesel production: A critical review. Sci Total Environ2021,768,144856.

20. Yuan,B.;Mahor,D.;Fei,Q.;Wever,R.;Alcalde,M.;Zhang,W.*;Hollmann,F.*,Water-Soluble Anthraquinone Photocatalysts Enable Methanol-Driven Enzymatic Halogenation and Hydroxylation Reactions. ACS Catalysis2020,10 (15),8277-8284.

21. Zhang,W.#;Lee,J.-H.#;Younes,S. H. H.;Tonin,F.;Hagedoorn,P.-L.;Pichler,H.;Baeg,Y.;Park,J.-B.*;Kourist,R.*;Hollmann,F.*,Photobiocatalytic synthesis of chiral secondary fatty alcohols from renewable unsaturated fatty acids. Nature Communications2020,11 (1),2258.

22. Zhang,W.#;Ma,M.#;Huijbers,M. M. E.#;Filonenko,G. A.;Pidko,E. A.;van Schie,M.;de Boer,S.;Burek,B. O.;Bloh,J. Z.;van Berkel,W. J. H.;Smith,W. A.;Hollmann,F.,Hydrocarbon Synthesis via Photoenzymatic Decarboxylation of Carboxylic Acids. Journal of the American Chemical Society2019,141 (7),3116-3120.

23. Zhang,W.;Fernández-Fueyo,E.;Ni,Y.;van Schie,M.;Gacs,J.;Renirie,R.;Wever,R.;Mutti,F. G.;Rother,D.;Alcalde,M.;Hollmann,F.*,Selective aerobic oxidation reactions using a combination of photocatalytic water oxidation and enzymatic oxyfunctionalizations. Nature Catalysis2018,1 (1),55-62.

24. Huijbers,M. M. E.#;Zhang,W.#;Tonin,F.;Hollmann,F.,Light-Driven Enzymatic Decarboxylation of Fatty Acids. Angewandte Chemie International Edition2018,57 (41),13648-13651.

25. Dong,J.;Fernández-Fueyo,E.;Hollmann,F.;Paul,C. E.;Pesic,M.;Schmidt,S.;Wang,Y.;Younes,S.;Zhang,W.,Biocatalytic Oxidation Reactions: A Chemist's Perspective. Angewandte Chemie International Edition2018,57 (30),9238-9261.