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  副研究员
 
姓名  
李键煚
性别  
专家类别  
N/A
职称  
高级工程师
学历  
硕士研究生
电话  
022-84861965
传真  
N/A
电子邮件  
li_jj@tib.cas.cn
地址  
天津市空港经济区西七道32号
邮编  
300308

简历

2023.10-至今,  中国科学院天津工业生物技术研究所,高级工程师

2014.04-2023.10,中国科学院天津工业生物技术研究所,助理研究员

2009.11-2014.04,中国科学院天津工业生物技术研究所,研究实习员

2008.06-2009.04,天津药明康德新药开发有限公司,合成部职员

2005.09-2008.06,河北师范大学,化学与材料科学学院,有机化学专业,硕士


研究方向:
  

生物催化反应工艺设计及优化,酶固定化


承担科研项目情况:
  

主持企业合作项目一项,天津市合成生物技术创新能力提升行动项目一项,参与国家重点研发计划项目、国家自然科学基金项目多项。


获奖及荣誉:
  


代表论著:

ACS Catal., Org. Lett., ChemCatChem等期刊发表学术论文20余篇,申请专利10件,已授权专利6件。

  1. Jianjiong Li,# Shanshan Yu,# Yingang Wang, Peiyuan Yao,* Qiaqing Wu,* Dunming Zhu*, Simultaneous Preparation of (S)-2-Aminobutane and d-α-Amino Acids via Biocatalytic Transamination at High Substrate Concentration, Org. Process Res. Dev., 2022, 26, 2013-2020.
  2. Linsong Yang,# Jianjiong Li,# Zefei Xu, Peiyuan Yao,* Qiaqing Wu, Dunming Zhu,* Yanhe Ma*, Asymmetric Synthesis of Fused-Ring Tetrahydroisoquinolines and Tetrahydro-β-carbolines from 2‑Arylethylamines via a Chemoenzymatic Approach, Org. Lett., 2022, 24, 6531-6536.
  3. Jiacheng Li, # Jianjiong Li, # Yunfeng Cui, Min Wang, Jinhui Feng, Peiyuan Yao,* Qiaqing Wu, Dunming Zhu*, Asymmetric Synthesis of Both Enantiomers of Dimethyl 2-Methylsuccinate by the Ene-Reductase-Catalyzed Reduction at High Substrate Concentration, Catalysts, 2022, 12, 1133.
  4. Jianjiong Li, Xi Chen, Yunfeng Cui, Weidong Liu, Jinhui Feng, Qiaqing Wu, Dunming Zhu, Enzymatic synthesis of d-alanine from a renewable starting material by co-immobilized dehydrogenases,Process Biochemistry, 2018, 66, 126-132.
  5. Peiyuan Yao, # Jianjiong Li, # Jing Yuan, Chao Han, Xiangtao Liu, Jinhui Feng, Qiaqing Wu,* Dunming Zhu*, Enzymatic Synthesis of a Key Intermediate for Rosuvastatin by Nitrilase-Catalyzed Hydrolysis of Ethyl (R)-4-Cyano-3-hydroxybutyate at High Substrate Concentration, ChemCatChem, 2015, 7, 271-275.
  6. Dunming Zhu, Jianjiong Li, Qiaqing Wu, Marine enzymes for biocatalysis (Stereoselective synthesis using marine enzymes), Woodhead publishing, 2013.