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  副研究员
 
姓名  
张玥
性别  
专家类别  
N/A
职称  
副研究员
学历  
博士研究生
电话  
022-24828752
传真  
022-24828752
电子邮件  
zhangy@tib.cas.cn
地址  
天津市空港经济区西七道32号
邮编  
300308

简历

1. 教育经历

2011.9-2017.6:天津大学,化工学院,制药工程专业,博士

2007.9-2011.6:南开大学,化学学院,化学专业,学士  

2. 工作经历

2021.6-至今:中国科学院天津工业生物技术研究所,副研究员

2017.7-2021.6:中国科学院天津工业生物技术研究所,助理研究员


研究方向:
  

在放线菌底盘内开发及应用基因组编辑、基于生物传感器和液滴微流控的高通量筛选等相关使能技术,解决底层关键共性技术难题;同时,在放线菌底盘内进行天然产物挖掘和高效生物合成机制解析,实现高附加值天然产物的生物制造及工程菌株的高通量智能铸造。

(Website: https://orcid.org/0000-0002-4383-6313


承担科研项目情况:
  

主持国家自然科学基金青年项目1项,国家重点研发计划子课题1项。以项目骨干身份参与国家自然科学基金、中国科学院先导项目、中国科学院重点部署项目等科研项目5项。


获奖及荣誉:
  

1.中国科学院青年创新促进会会员(No. 2023187)

2. 中国科学院第四届“科苑名匠”(工程菌种铸造科学设施团队)


代表论著:

  1. Yue Zhang*, Xuemei Zhang, Meng Wang*. Product-driven high-throughput screening of industrial filamentous actinomycetes. Trends in Biotechnology, 2023, 41(9): 1109-1112.
  2. Jin Wang, Ning Xue, Wenjia Pan, Ran Tu, Shixin Li, Yue Zhang, Yufeng Mao, Ye Liu, Haijiao Cheng, Yanmei Guo, Wei Yuan, Xiaomeng Ni, Meng Wang*. Repurposing conformational changes in ANL superfamily enzymes to rapidly generate biosensors for organic and amino acids. Nature Communications, 2023, 14(1): 6680.
  3. Yan Wang, Shixin Li, Ning Xue, Lixian Wang, Xuemei Zhang, Longqian Zhao, Yanmei Guo, Yue Zhang*, Meng Wang*. Modulating sensitivity of an erythromycin biosensor for precise high-throughput screening of strains with different characteristics. ACS Synthetic Biology, 2023, 12(6): 1761-1771.
  4. Xuemei Zhang, Yan Wang, Yue Zhang*, Meng Wang*. CRISPR/Cas9-Mediated Multi-Locus Promoter Engineering in ery Cluster to Improve Erythromycin Production in Saccharopolyspora erythraea. Microorganisms, 2023, 11: 623.
  5. Erbing Hua#, Yue Zhang#*, Kaiyue Yun, Wenjia Pan, Ye Liu, Shixin Li, Yan Wang, Ran Tu*, Meng Wang*. Whole-cell biosensor and producer co-cultivation-based microfludic platform for screening Saccharopolyspora erythraea with hyper erythromycin production. ACS Synthetic Biology, 2022, 11(8): 2697-2708.(封面文章)
  6. Kaiyue Yun#, Yue Zhang#, Shixin Li, Yan Wang, Ran Tu, Hao Liu*, Meng Wang*. Droplet-Microfluidic-Based Promoter Engineering and Expression Fine-Tuning for Improved Erythromycin Production in Saccharopolyspora erythraea NRRL 23338. Frontiers in Bioengineering and Biotechnology, 2022, 10: 864977.
  7. Yue Zhang, Kaiyue Yun, Huamei Huang, Ran Tu, Erbing Hua, Meng Wang*. Antisense RNA interference-enhanced CRISPR/Cas9 base editing method for improving base editing efficiency in Streptomyces lividans 66. ACS Synthetic Biology, 2021, 10(5): 1053-1063.(封面文章)
  8. Ran Tu#, Yue Zhang#, Erbing Hua, Likuan Bai, Huamei Huang, Kaiyue Yun, Meng Wang*. Droplet-based microfluidic platform for high-throughput screening of Streptomyces. Communications Biology, 2021, 4: 647.
  9. Xiao Wen, Yue Zhang, Haijiao Cheng, Jingjing An, Yanmei Guo, Lixian Wang, Meng Wang. A CRISPR/dCas9-assisted system to clone toxic genes in Escherichia coli. Biochimica et Biophysica Acta (BBA) - General Subjects, 2021, 1865(11): 129994.
  10. Chun-Yan Lin#, Yue Zhang#, Ji-Hua Wu, Rong-Hui Xie, Jianjun Qiao, Guang-Rong Zhao*. Regulatory Patterns of Crp on Monensin Biosynthesis in Streptomyces cinnamonensis. Microorganisms, 2020, 8(2): 271.
  11. Chun-Yan Lin, Ai-Ping Pang, Yue Zhang, Jianjun Qiao, Guang-Rong Zhao*. Comparative Transcriptomic Analysis Reveals the Significant Pleiotropic Regulatory Effects of LmbU on Lincomycin Biosynthesis. Microbial Cell Factories, 2020, 19(1): 30.
  12. Han Xiao#*, Yue Zhang#, Meng Wang*. Discovery and engineering of cytochrome P450s for terpenoid biosynthesis. Trends in Biotechnology, 2019, 37(6): 618-631.