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姓名 |
孙涛 |
性别 |
男 |
专家类别 |
N/A |
职称 |
高级工程师 |
学历 |
硕士研究生 |
电话 |
022-84861948 |
传真 |
022-84861948 |
电子邮件 |
sun_t@tib.cas.cn |
地址 |
天津市空港经济区西七道32号 |
邮编 |
300308 |
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简历 |
1. 教育经历 2007/09-2011/07 山东农业大学,生命科学学院,生物工程,学士 2011/09-2014/06 天津科技大学,生物工程学院,发酵工程,硕士 2. 工作经历 2014/06-2021/06 中国科学院天津工业生物技术研究所,工程师 2021/06-至今 中国科学院天津工业生物技术研究所,高级工程师 |
研究方向: |
主要从事工业丝状真菌发酵L-苹果酸、纤维素乙醇、L-乳酸等大宗化学品和糖化酶等工业蛋白质的生产过程优化控制与放大研究,开发了基于组学指导和多参数分析的秸秆一步发酵技术,实现了秸秆生物质直接发酵高效合成化学品的规模测试,参与建成国内外第一条年产万吨L-苹果酸生产线。 |
承担科研项目情况: |
国家自然科学基金委,青年项目,酿酒酵母内外源杂合半乳糖代谢途径构建和优化,2018.01-2020.12,主持 天津市合成生物技术创新能力提升行动,生物质转化生产苹果酸发酵工艺优化及规模放大,2021.04-2024.03,主持 参与国家重点研发计划、中国科学院先导专项课题、国家自然科学基金委面上项目及企业委托重大项目等各类科研项目10余项。 |
代表论著: |
在Metab Eng等期刊发表论文10余篇,申请专利10余项。
- Wang H#, Sun T#, Zhao Z, Gu S, Liu Q, Wu T, Wang D, Tian C, Li J*. Transcriptional Profiling of Myceliophthora thermophila on Galactose and Metabolic Engineering for Improved Galactose Utilization. Front Microbiol. 2021;12.
- Zhang Y, Sun T, Wu T, Li J, Hu D, Liu D, Li J, Tian C*. Consolidated bioprocessing for bioethanol production by metabolically engineered cellulolytic fungus Myceliophthora thermophila. Metab Eng. 2023; 78:192-199.
- Li J, Lin L, Sun T, Xu J, Ji J, Liu Q, Tian C*. Direct production of commodity chemicals from lignocellulose using Myceliophthora thermophila. Metab Eng. 2019;61 (2020 ):416–26.
- Zhao J, Li Q, Sun T, Zhu X, Xu H, Tang J, Zhang X*, Ma Y. Engineering central metabolic modules of Escherichia coli for improving β-carotene production. Metab Eng. 2013; 17:42-50.
- Sun T, Miao L, Li Q, Dai G, Lu F, Liu T, Zhang X*, Ma Y. Production of lycopene by metabolically-engineered Escherichia coli. Biotechnol Lett. 2014;36(7):1515-22.
- Li, J; Zhang, Y; Li, J; Sun, T; Tian, C*. Metabolic engineering of the cellulolytic thermophilic fungus Myceliophthora thermophila to produce ethanol from cellobiose. Biotechnol Biofuels 2020,13:23.
- Zhu Z, Zhang M, Liu D, Liu D, Sun T, Yang Y,Dong J, Zhai h, Sun W, Liu Q, Tian C*. Development of the thermophilic fungus Myceliophthora thermophila into glucoamylase hyperproduction system via the metabolic engineering using improved AsCas12a variants. Microb Cell Fact.2023 ;11;22(1):150.
- Guo W, Liu D, Li J, Sun W, Sun T,Wang X, Wang K, Liu Q, Tian C*. Manipulation of an α-glucosidase in the industrial glucoamylase-producing Aspergillus niger strain O1 to decrease non-fermentable sugars production and increase glucoamylase activity. Front Microbiol. 2022;20:13.
- Li J#, Chen B#, Gu S#, Zhao Z, Liu Q, Sun T, Zhang Y, Wu T, Liu D, Sun W, Tian C*. Coordination of consolidated bioprocessing technology and carbon dioxide fixation to produce malic acid directly from plant biomass in Myceliophthora thermophila. Biotechnol Biofuels. 2021;14(1):186.
- Gu, S#; Li, J#; Chen, B; Sun, T; Liu, Q; Xiao, D; Tian, C* Metabolic engineering of the thermophilic filamentous fungus Myceliophthora thermophila to produce fumaric acid. Biotechnol Biofuels. 2018, 11.13, 23.
- Li, J; Gu, S; Zhao, Z; Chen, B; Liu, Q; Sun, T; Sun, W; Tian, C* Dissecting cellobiose metabolic pathway and its application in biorefinery through consolidated bioprocessing in Myceliophthora thermophila. Fungal Biol Biotechnol. 2019, 6, 21.
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