2023.12-至今 中国科学院天津工业生物技术研究所 副研究员

2018.07-2023.12 中国科学院天津工业生物技术研究所 博士后

2012.09 -2018.07 中国科学院大学 硕转博

植物天然产物合成；酵母基因组工程

针对具有重要药用价值和应用价值的植物天然产物，从“生物元件的功能筛选与设计改造”和“细胞工厂的系统构建与过程优化”两方面开展系统研究。结合基因组学、计算生物学、合成生物学方法，解析自然界植物天然产物复杂的生物代谢途径、探究生物合成的基本规律与生物催化的反应机理，对天然产物合成过程涉及的关键催化元件进行挖掘和改造、对微生物宿主细胞进行代谢工程及生产过程优化，革新植物天然产物制造模式。已成功实现心脑血管疾病特效药灯盏乙素、美白剂根皮素、抗炎化合物白杨素及其衍生物、甜味剂新橙皮苷查耳酮、抗抑郁新药物苔黑酚糖苷、抗癌药物紫杉醇中间体等20余种化合物的生物合成。

国家自然科学基金委，面上项目，紫杉二烯-5α-羟化酶催化混杂性机制解析与理性设计，2024.01-2027.12，主持

国家自然科学基金委，青年基金，黄酮8-O-甲基转移酶功能解析与催化机理研究，2020.01- 2022.12，主持

中国博士后科学基金，紫杉醇生物合成机制的研究，2019.11-2021.11，主持

2018年 中国科学院院长优秀奖

2018年 中国科学院优秀毕业生

以第一作者、共同一作或通讯作者在Molecular Plant、Nature Communications、Science  China  Life  Sciences、PloS Biology等期刊发表学术论文17篇，申请发明专利9项。

代表论著：

1. Xiaonan Liu*#, Xiaoxi Zhu, Jian Cheng, Huifeng Jiang. A new era for paclitaxel biosynthesis is coming. Molecular Plant 2024, Jan 18: S1674-2052(24)00005-4. (一作，共同通讯，IF: 27.5, Q1)
2. Bihuan Chen*, Xiaonan Liu*, Yina Wang*, Jie Bai*, Xiangyu Liu, Guisheng Xiang, Wei Liu, Xiaoxi Zhu, Jian Cheng, Lina Lu, Guanghui Zhang, Shuhui Zi#, Shengchao Yang# and Huifeng Jiang#. Production of the antidepressant orcinol glucoside in Yarrowia lipolytica with yields over 6,400-fold higher than plant extraction. Plos biology 2023, 21(6): e3002131. (共同一作，IF: 9.8, Q1)
3. Yuqian Liu*, Qian Wang*, Xiaonan Liu*, Jian Cheng*#, Lei Zhang, Huanyu Chu, Ruoyu Wang, Haoran Li, Hong Chang, Nida Ahmed, Zhonghua Wang, Xiaoping Liao# and Huifeng Jiang#. pUGTdb: A comprehensive database of plant UDP-dependent glycosyltransferases. Molecular Plant 2023, S1674-2052(23)00003-5. (共同一作，IF: 27.5, Q1)
4. Xiaonan Liu*, Jian Cheng*, Guanghui Zhang*, Wentao Ding, Lijin Duan, Jing Yang, Ling Kui, Xiaozhi Cheng, Jiangxing Ruan, Wei Fan, Junwei Chen, Guangqiang Long, Yan Zhao, Jing Cai, Wen Wang, Yanhe Ma, Yang Dong, Shengchao Yang# and Huifeng Jiang#. Engineering yeast for the production of breviscapine by genomic analysis and synthetic biology approaches. Nature Communications 2018, 9 (1): 448. (一作，IF: 16.6, Q1)
5. Jian Cheng*, Xiao Wang*, Xiaonan Liu*, Xiaoxi Zhu*, Zihe Li, Huanyu Chu, Qian Wang, Qianqian Lou, Bijun Cai, Yiqun Yang, Xiaoyun Lu, Kai Peng, Dingyu Liu, Yuwan Liu, Lina Lu, Huan Liu, Ting Yang, Qijin Ge, Chengcheng Shi, Guichun Liu, Zhiwei Dong, Xun Xu#, Wen Wang#, Huifeng Jiang# and Yanhe Ma. Chromosome-level genome of Himalayan yew provides insights into the origin and evolution of the paclitaxel biosynthetic pathway. Molecular Plant 2021, 14(7): 1199-1209. (共同一作，IF: 27.5, Q1)
6. Xiaonan Liu*, Jian Cheng*, Xiaoxi Zhu, Guanghui Zhang, Shengchao Yang, Xiaoxian Guo#, Huifeng Jiang# and Yanhe Ma. De Novo Biosynthesis of Multiple Pinocembrin Derivatives in Saccharomyces cerevisiae. ACS Synthetic Biology 2020, 9 (11): 3042-3051. (一作，IF: 4.7, Q2)
7. Chunmei Jiang*, Xiaonan Liu*, Xianqing Chen, Yi Cai, Yibin Zhuang, Tao Liu, Xiaoxi Zhu, Hui Wang, Yuwan Liu, Huifeng Jiang and Wen Wang#. Raising the production of phloretin by alleviation of by-product of chalcone synthase in the engineered yeast. Science China Life sciences 2020, 63(11): 1734-1743. (共同一作，IF: 9.1, Q1)
8. Xiaoxi Zhu*, Xiaonan Liu*, Tian Liu, Yina Wang, Nida Ahmed, Zhichao Li# and Huifeng Jiang#. Synthetic biology of plant natural products: From pathway elucidation to engineered biosynthesis in plant cells. Plant Communications 2021,2(5): 100229. (共同一作，IF: 10.5, Q1)
9. Xiaonan Liu*, Xiaoxi Zhu*, Hui Wang, Tian Liu, Jian Cheng and Huifeng Jiang#. Discovery and modification of cytochrome P450 for plant natural products biosynthesis. Synthetic and systems biotechnology 2020, 5 (3): 187-199. (一作，IF: 4.8, Q2)
10. Jian Cheng*, Jing Chen*, Xiaonan Liu*, Xiangchen Li, Weixiong Zhang, Zhubo Dai, Lina Lu, Xiang Zhou, Jing Cai#, Xueli Zhang#, Huifeng Jiang# and Yanhe Ma. The origin and evolution of the diosgenin biosynthetic pathway in yam. Plant Communications 2020,2(1): 100079. (共同一作，IF: 10.5, Q1)
11. Tian Liu*, Yuqian Liu*, Lan Li*, Xiaonan Liu*, Zhaokuan Guo, Jian Cheng, Xiaoxi Zhu, Lina Lu, Junlin Zhang, Guanwei Fan, Nengzhong Xie#, Jian Lu# and Huifeng Jiang#. De Novo Biosynthesis of Polydatin in Saccharomyces cerevisiae. Journal of agricultural and food chemistry 2021, 69(21): 5917-5925. (共同一作，IF: 6.1, Q1)
12. Yina Wang*#, Xiaonan Liu*#, Bihuan Chen, Wei Liu, Zhaokuan Guo, Xiangyu Liu, Xiaoxi Zhu, Jiayu Liu, Jin Zhang, Jing Li, Lei Zhang, Yadi Gao, Guanghui Zhang, Yan Wang, M. Iqbal Choudhary, Shengchao Yang# and Huifeng Jiang#. Metabolic engineering of Yarrowia lipolytica for scutellarin production. Synthetic and Systems Biotechnology 2022, 7(3): 958-964. (共同一作，共同通讯，IF: 4.8, Q2)
13. Xiangchen Li*, Jian Cheng*, Xiaonan Liu*, Xiaoxian Guo, Yuqian Liu, Wenjing Fan, Lina Lu, Yanhe Ma, Tao Liu, Shiheng Tao# and Huifeng Jiang#. Origin and Evolution of Fusidane-Type Antibiotics Biosynthetic Pathway through Multiple Horizontal Gene Transfers. Genome Biology and Evolution 2020, 12 (10): 1830-1840. (共同一作，IF: 3.3, Q2)
14. Xiaonan Liu*, Wentao Ding* and Huifeng Jiang#. Engineering microbial cell factories for the production of plant natural products: from design principles to industrial-scale production. Microbial Cell Factories 2017, 16 (1): 125. (一作，IF: 6.4, Q2)
15. Lijin Duan*, Wentao Ding*, Xiaonan Liu, Xiaozhi Cheng, Jing Cai, Erbing Hua#, Huifeng Jiang#. Biosynthesis and engineering of kaempferol in Saccharomyces cerevisiae 2017, 16 (1):165. (IF: 6.4, Q2)

专利

1. 江会锋，刘晓楠，丁文涛，程健，阮江星，段立津，卢丽娜。黄酮-6-羟化酶及其在灯盏乙素合成中的应用（ZL2016108244709 已授权）

2. 陈贤情，刘晓楠，江会锋 王筱，王文。一种酿酒酵母发酵生产根皮素的方法（ZL 201710934514.8 已授权）

3. 江会锋，刘晓楠，程健，卢丽娜。黄酮-8-羟化酶及其在8-羟基黄酮化合物合成中的应用 （ZL201911369033.2 已授权）

4. 江会锋，刘晓楠，程健，卢丽娜。黄酮-O-甲基转移酶及其在汉黄芩素、异汉黄芩素和苏荠苧黄酮合成中的应用（ZL202010117745.1 已授权）

5. 江会锋，刘甜，刘晓楠，刘宇倩，祝晓熙，程健，卢丽娜。白藜芦醇-3-糖基转移酶及其在虎杖苷合成中的应用（ZL202110114132.7已授权）

6. 江会锋，王益娜，刘晓楠，陈碧环，刘伟，卢丽娜，张广辉，杨生超。一种产灯盏乙素的重组解脂耶氏酵母及其构建方法和用途（ZL 202210476510.0已授权）