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  副研究员
 
姓名  
魏亮
性别  
专家类别  
N/A
职称  
副研究员
学历  
博士研究生
电话  
N/A
传真  
N/A
电子邮件  
weil@tib.cas.cn
地址  
天津市空港经济区西七道32号
邮编  
300308

简历

2008.09-2012.07,山东农业大学,生物工程专业,学士学位;

2012.09-2015.07,天津大学,生物化工专业,硕士学位;

2015.09-2019.07,中国科学院天津工业生物技术研究所,微生物学专业,博士学位;

2019.07-2022.07,中国科学院天津工业生物技术研究所,博士后;

2022.09-至今,中国科学院天津工业生物技术研究所,副研究员。


研究方向:
  

阐明重要工业微生物合成特定代谢产物的分子基础和调控机制,并利用代谢工程、合成生物技术、生物传感技术等方法,构建高效微生物细胞工厂,生产氨基酸、有机酸以及高附加值化学品。


承担科研项目情况:
  

主持国家自然科学基金青年项目1项、天津市自然科学基金青年项目各1项、博士后面上基金1项,以及天津市合成生物技术创新能力提升行动项目。


获奖及荣誉:
  


代表论著:

[1] Yun Ju, Hongyu Zhang, Xiaocong Du, Jingxuan Wei, Jun Liu,Liang Wei*, Qingdai Liu*, Ning Xu*.DRAGON: Harnessing the power of DNA repair for accelerating genome evolution in Corynebacterium glutamicum[J].Metabolic Engineering, 2023, 79: 182-191.

[2] Huanmin Du, Yuting Qi, Jinfang Qiao, Lingcong Li, Ning Xu, Li Shao, Liang Wei*, and Jun Liu*. Balancing Redox Homeostasis to Improve l-Cysteine Production in Corynebacterium glutamicum[J]. Journal of Agricultural and Food Chemistry, 2023, 71(37): 13848-13856.

[3] Huanmin Du, Jinfang Qiao, Yuting Qi, Lingcong Li, Ning Xu, Li Shao, Liang Wei*and Jun Liu*. Reprogramming the sulfur recycling network to improve l-cysteine production in Corynebacterium glutamicum[J]. Green Chemistry, 2023, 25(8): 3152-3165.

[4] Jinshan Gao, Muhua Du, Jinhua Zhao, Yue zhang, Ning Xu, Huanmin Du, Jiansong Ju, Liang Wei*, Jun Liu*. Design of a genetically encoded biosensor to establish a high-throughput screening platform for L-cysteine overproduction[J]. Metabolic Engineering, 2022, 73: 144-157.

[5] Liang Wei, Jinhua Zhao, Yiran wang, Jinshan Gao, Muhua Du, Yue zhang, Ning Xu, Huanmin Du, Jiansong Ju, Qingdai Liu*, Jun Liu*. Engineering of Corynebacterium glutamicum for high-level γ-aminobutyric acid production from glycerol by dynamic metabolic control[J]. Metabolic Engineering, 2022, 69: 134-146.

[6] Liang Wei, Qian Wang, Ning Xu, Jian Cheng, Wei Zhou, Guoqiang Han, Huifeng Jiang*, Jun Liu*, and Yanhe Ma.Combining protein and metabolic engineering strategies for high-level production of O-acetylhomoserine in Escherichia coli[J]. ACS Synthetic Biology, 2019, 8(5): 1153-1167.

[7] Liang Wei, Hao Wang, Ning Xu, Wei Zhou, Jiansong Ju*, Jun Liu*, Yanhe Ma. Metabolic engineering of Corynebacterium glutamicum for L-cysteine production[J]. Applied microbiology and biotechnology, 2019, 103: 1325-1338.

[8] Liang Wei, Ning Xu, Yiran Wang, Wei Zhou, Guoqiang Han, Yanhe Ma & Jun Liu*. Promoter library-based module combination (PLMC) technology for optimization of threonine biosynthesis in Corynebacterium glutamicum[J]. Applied microbiology and biotechnology, 2018, 102: 4117-4130.

[9] Liang Wei, Jiao Liu, Haishan Qi, Jianping Wen. Engineering Scheffersomyces stipitis for fumaric acid production from xylose[J]. Bioresource technology, 2015, 187: 246-254.