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  副研究员
 
姓名  
袁波
性别  
专家类别  
N/A
职称  
副研究员
学历  
博士研究生
电话  
022-24828717
传真  
N/A
电子邮件  
yuanb@tib.cas.cn
地址  
天津市空港经济区西七道32号
邮编  
300308

简历

1. 教育经历

2007.10-2011.12, 英国曼彻斯特大学,生物化学,博士,导师:Nicholas J. Turner教授

2006.9-2007.9, 英国曼彻斯特大学,高分子材料与工程,硕士

2002.9-2006.6, 中山大学,应用化学,理学学士

2. 工作经历 

2021.03-至今,中国科学院天津工业生物技术研究所,生物催化研究中心,副研究员

2016.12- 2021.2,西安交通大学,化学工程与技术学院,讲师、副教授

2011.12-2016.1,英国禾大化学品公司,研发工程师


研究方向:
  

高值手性医药中间体的生物酶法不对称合成是生物制造的重要发展领域,符合我国十四五的战略发展方向。不对称生物催化合成医药中间体是将生命科学、化学与工程等学科紧密交叉与结合的前沿科学技术,也是一种低碳、绿色、安全、高效的应用技术,在生物医药产业发展中具有广阔的应用前景及巨大的经济价值。团队重点开展酶设计与功能重塑、生物催化新反应设计、酶固定化及连续流工艺开发等方向的基础与应用研究。

具体研究方向如下:

1. 化酶级联合成重要手性药物中间体。利用氧化还原酶包括半乳糖氧化酶、卤化酶等酶催化的动力学拆分、去消旋化反应进行复杂分子的合成


1 沙库巴曲双手性药物中间体合成

  1. 轴手性化合物的生物催化合成反应。筛选、表征及设计新型人工酶催化轴手性化合物的合成

2 亚胺还原酶及其突变体催化轴手性联芳基胺类化合物的合成及机制解析

  1. 酶固定化及连续流催化工艺体系创制与应用。利用新型功能性材料进行酶固定化体系创制与连续流工艺开发应用于重要医药中间体的工业级合成。

3 酶固定化及连续流催化工艺体系创制与应用


承担科研项目情况:
  

中国科学院C类战略性先导科技专项,课题负责人

国家重点研发计划2项,子课题负责人

国家自然科学基金委员会面上项目,项目负责人

国家自然科学基金青年项目,项目负责人

天津市合成生物技术创新能力提升行动项目,项目负责人


获奖及荣誉:
  

2010年国家优秀自费留学生奖学金

学术兼职:

国际期刊BioDesign Research青年编委


代表论著:

[1]  P. Zhang#, B. Yuan#, J. Li, C. Li, J. Guo, B. Zhang, G. Qu, H. Su, N. J. Turner, Z. Sun*, Biocatalytic Desymmetrization for the Atroposelective Synthesis of Axially Chiral Biaryls Using an Engineered Imine Reductase, Angew. Chem. Int. Ed, 2024, e202416569.

[2]  J. Li#, B. Yuan#, C. Li, Z. Zhao, J. Guo, P. Zhang, G. Qu, Z. Sun*, Stereoselective Synthesis of Oxetanes Catalyzed by anEngineered Halohydrin Dehalogenase, Angew. Chem. Int. Ed, 2024, e202411326.

[3]  P. Xie, J. Lan, J. Zhou, Z. Hu, J. Cui, G. Qu, B. Yuan*, Z. Sun*, Co-immobilization of amine dehydrogenase and glucose dehydrogenase for the biosynthesis of (S)-2-aminobutan-1-ol in continuous flow. Bioresour. Bioprocess, 2024, 11, 70.

[4]  B. Yuan*, D. Yang, G. Qu, N. J. Turner* and Z. Sun*, Biocatalytic Reductive Aminations with NAD(P)H-Dependent Enzymes: Enzyme Discovery, Engineering and Synthetic Applications, Chem Soc Rev, 2024, 53, 227.

[5]  M. Ye, C. Li, D. Xiao, G. Qu, B. Yuan* and Z. Sun*, Atroposelective Synthesis of Aldehydes via Alcohol Dehydrogenase-Catalyzed Stereodivergent Desymmetrization, JACS Au, 2024, 4, 411.

[6]  X. Li, J. Wang, W. Su, C. Li, G. Qu, B. Yuan* and Z. Sun*, Characterization and Engineering of Cephalosporin C Acylases to Produce 7-Aminocephalosporanic Acid, Mol. Catal, 2023, 550, 113595.

[7]  Y. Li, C. Bao, Z. Sun, W. Zhang* and B. Yuan*, Comparison Between Chemoenzymatic and Bienzymatic Cascades Leading to Morita–Baylis–Hillman Adducts, ChemCatChem, 2023, 15, e202201621.

[8]  W. Huang, S. Huang, Z. Sun, W. Zhang, Z. Zeng* and B. Yuan*, Chemoenzymatic Synthesis of Sterically Hindered Biaryls by Suzuki Coupling and Vanadium Chloroperoxidase Catalyzed Halogenations, ChemBioChem, 2023, 24, e202200610.

[9]  S. Song#, Y. Jiang#, R. Chen, W. Su, W. Liang, D. Yang, J. Li, W. Zhang, S. Gao, B. Yuan*, G. Qu*, Z. Sun*, Whole-Cell Biotransformation of Penicillin G by a Three-Enzyme Co-expression System with Engineered Deacetoxycephalosporin C Synthase. ChemBioChem, 2022, 23, e202200179.

[10]  B. Yuan, D. Mahor, Q. Fei, R. Wever, M. Alcalde, W. Zhang*, F. Hollmann*, Water-Soluble Anthraquinone Photocatalysts Enable Methanol Driven Enzymatic Halogenation and Hydroxylation Reactions, ACS Catalysis, 2020, 10, 8277.

[11]  B. Yuan, D. Debecker, X. Wu, J. Xiao, Q. Fei*, N. J. Turner*, One-pot Chemoenzymatic Deracemisation of Secondary Alcohols Employing Variants of Galactose Oxidase and Transfer Hydrogenation, Chemcatchem, 2020, 12, 6191.

[12]  B. Yuan, A. Page, C. P. Worrall, F. Escalettes, S. C. Willies, J. J. W. McDouall, N. J. Turner* and J. Clayden*, Biocatalytic Desymmetrization of an Atropisomer with both an Enantioselective Oxidase and Ketoreductases, Angew. Chem. Int. Ed, 2010, 49, 7010.

[13]  T. Cui#, B. Yuan#, H. Guo, H. Tian, W. Wang, Y. Ma, C. Li, Q. Fei*Enhanced Lignin Biodegradation By Consortium Of White Rot Fungi: Microbial Synergistic Effects And Product Mapping, BIOTECHNOL BIOFUELS, 2021, 14, 162.

[14]  B. Yuan, F. Escalettes, N. J. Turner*, Practical Methods for Biocat. and Biotrans. 2, Chapter 6.2 & Chapter 6.3, 2012, John Wiley & Sons, Ltd.

[15]  Qin Z, Yuan B, Qu G*, Sun Z*. Rational enzyme design by reducing the number of hotspots and library size. Chem. Commun., 2024, 60, 10451-10463.

[16]  H. Ming, B. Yuan, G. Qu*, Z. Sun*, Engineering the activity of Amine Dehydrogenase in the Asymmetric Reductive Amination of Hydroxyl Ketones, Catal. Sci. Technol, 2022, 12, 5952.

[17]  Y. Li, B. Yuan, Z. Sun, W. Zhang* C-H Bond Functionalization Reactions Enabled by Photobiocatalytic Cascades, 2021, Green Synth. Catal., 2, 267.

[18]  S. Staniland, B. Yuan, N. Gimenez-Agullo, T. Marcelli, S. C. Willies, D. M. Grainger, N. J. Turner*, and J. Clayden*, Enzymatic Desymmetrising Redox Reactions for the Asymmetric Synthesis of Biaryl Atropisomers, Chem. Eur. J., 2014, 20, 13084.

[19]  Li Y, Yuan B, Sun Z, Zhang W. C–H bond functionalization reactions enabled by photobiocatalytic cascades. Green Synth. Catal., 2021, 2 (3), 267-274.

[20]  Li X, Li C, Qu G, Yuan B, Sun Z*. Engineering of a Baeyer-Villiger monooxygenase to improve substrate scope, stereoselectivity and regioselectivity. ChemBioChem, 2024, e202400328.

[21]  Wang Q, Li C, Yuan B, Yu A, Qu G*, Sun Z*. Engineering the activity of a newly identified arylalkylamine N-acetyltransferase in the acetylation of 5-hydroxytryptamine. ChemBioChem, 2024, e202400069.

[22]  Ren Y, Qin Z, Li C, Yuan B, Yang Y, Qu G*, Sun Z*.Engineering the activity and thermostability of a carboxylic acid reductase in the conversion of vanillic acid to vanillin. J. Biotechnol., 2024, 386, 19-27.

[23]  Paul C, Hanefeld U, Hollmann F*, Qu G, Yuan B, Sun Z. Enzyme engineering for biocatalysis. Mol. Catal., 2024, 555, 113874.

[24]  Sang X, Tong F, Zeng Z, Wu M, Yuan B, Sun Z, Sheng X, Qu G, Alcalde M, Hollmann F, Zhang W. A Biocatalytic Platform for the Synthesis of Enantiopure Propargylic Alcohols and Amines. Org. Lett., 2022, 24(23), 4252-4257.

[25]  罗佳慧, 李聪聪, 叶梦静, 张鹏鹏, 曲戈, 蔡志强, 王车礼, 袁波*, 孙周通*. 含吡咯及吲哚基团的N-N轴手性化合物的酶催化合成[J]. 生物工程学报, 1-14. 10.13345/j.cjb.240512.

[26]  曲戈, 袁波, 孙周通. 工业蛋白质理性设计与应用[J]. 生物工程学报, 2022, 38(11): 4068-4080.

[27]  尚亚莉, 袁波, 费强. 生物催化轴手性化合物的不对称合成进展[J]. 高校化学工程学报, 2021, 35(5):14. 10.3969/j.issn.1003-9015.2021.05.003.

[28]  张武元, 袁波, 曲戈, 孙周通. 光促酶催化反应设计及生物合成应用[J]. 生物学杂志, 2021, 38(5): 1. 特约综述.

申请及授权发明专利

[1]  袁波, 孙周通, 张鹏鹏, 陈龙, 罗佳慧,一种沙库巴曲中间体的合成方法, 2023112695532, 2023.9.28

[2]  袁波, 孙周通, 李湘莹, 苏文成,一种头孢菌素C酰化酶的人工合成及其突变体应用,202210655746.0, 2022.6.10

[3]  袁波, 孙周通, 李湘莹, 苏文成,一种头孢菌素C酰化酶突变体及其应用, 202210655745.6, 2022.6.10

[4]  袁波, 宋世怡, 李湘莹, 苏文成, 蒋迎迎, 曲戈, 孙周通, 张武元, 扩环酶及其突变体在生产G-7-ADCA中的应用, CN202110676893.1, 2021.6.18

[5]  孙周通, 袁波, 苏文成, 李湘莹,一种头孢菌素C酰化酶催化的酰化反应及其应用,202210655575.1 2022.6.10

[6]  孙周通, 袁波, 苏文成, 李湘莹, 李金成,头孢菌素C酰化酶突变体及其在头孢菌素母核合成中的应用,202210655545.02022.6.10

[7]  孙周通, 杨大猛, 李湘莹, 苏文成, 蒋迎迎, 曲戈, 张武元, 袁波,一种生产7-氨基去乙酰氧基头孢烷酸的方法,202111097082.2