主要研究领域包括工业酶制剂的挖掘、分子改造及高效表达、原核表达系统构建及相关机制研究、微生物应用技术等。目前研究兴趣在于原核表达宿主菌的代谢调控机制研究，从而实现大肠杆菌和芽胞杆菌宿主细胞的定向改造及细胞工厂的创建。
代表论著：
发表科技论文20余篇，其中以一作或通讯作者发表SCI论文10篇；申请发明专利10项，已授权5项。
1. Zeng Y, Xu J, Fu X, Tan M, Liu F*, Zheng H*, Song H*. Effects of different carbohydrate-binding modules on the enzymatic properties of pullulanase. Int J Biol Macromol. 2019, 137:973-981.
2. Zheng H#, Yu Z#, Shu W#, Fu X, Zhao X, Yang S, Tan M, Xu J, Liu Y*, Song H*. Ethanol effects on the overexpression of heterologous catalase in Escherichia coli BL21 (DE3). Appl Microbiol Biotechnol. 2019, 103(3): 1441-1453.
3. Zeng Y#, Zheng H#, Shen Y, Xu J, Tan M, Liu F, Song H*. Identification and analysis of binding residues in the CBM68 of pullulanase PulA from Anoxybacillus sp. LM18-11. J. Biosci. Bioeng. 2019, 127(1): 8-15.
4. Zhao X#, Xu J#, Tan M, Yu Z, Yang S, Zheng H*, Song H*. Construction of a plasmid interspecific transfer system in Bacillus species with the counter-selectable marker mazF. J Ind Microbiol Biotechnol. 2018, 45(6):417-428.
5. Yu Z#, Zheng HC#, Zhao X, Li S, Xu J, Song H*. High level extracellular production of a recombinant alkaline catalase in E. coli BL21 under ethanol stress and its application in hydrogen peroxide removal after cotton fabrics bleaching. Bioresour Technol. 2016, 214: 303-310.
6. Zheng HC, Yu Z, Fu X, Li S, Xu J, Song H*, Ma Y. High level extracellular production of a truncated alkaline β-mannanase from alkaliphilic Bacillus sp. N16-5 in Escherichia coli by the optimization of induction condition and fed-batch fermentation. J Ind Microbiol Biotechnol. 2016, 43(7):977-87.
210:8-14.
7. Zheng Hongchen#, Yihan Liu#, Mingzhe Sun, Yang Han, Jianling Wang, Junshe Sun, Fuping Lu*. Improvement of alkalistability and thermostability of Paenibacillus campinasensis Family-11 xylanase by directed evolution and site-directed mutagenesis. J Ind Microbiol Biotechnol. 2014, 41(1): 153-62.
8. Zheng Hongchen#, Yihan Liu#, Xiaoguang Liu, Yang Han, Jianling Wang, Fuping Lu*. Overexpression of a Paenibacillus campinasensis xylanase in Bacillus megaterium and its applications to biobleaching of cotton stalk pulp and saccharification of recycled paper sludge. Bioresource Technology. 2012, 125: 182-187.
