2015年获武汉大学生物化学与分子生物学专业博士学位

2016年至2021年，瑞典查尔姆斯理工大学，博士后研究

2022年至2023年，丹麦科技大学，博士后研究

2024年至今，中国科学院天津工业生物技术研究所，研究员，博士生导师

微生物细胞工厂，细胞代谢工程，合成生物学前沿技术，生物基产品，生物基聚合物单体

# Equal contribution. * Corresponding author. Full list please visit https://orcid.org/0009-0008-2436-7524.

Xin Chen*,Feiran Li,Xiaowei Li,Maximilian Otto,Yu Chen,Verena Siewers*. Model-assisted CRISPRi/a library screening reveals central carbon metabolic targets for enhanced recombinant protein production in yeast. Metabolic Engineering,2025,88: 1-13.

Xiaowei Li,Adrian E Gadar-Lopez,Ling Chen,Sidharth Jayachandran,Pablo Cruz-Morales*,Jay D Keasling*. Mining natural products for advanced biofuels and sustainable bioproducts[J]. Current Opinion in Biotechnology,2023,84: 103003.

Jiwei Mao,Marta Tous Mohedano,Jing Fu,Xiaowei Li,Quanli Liu,Jens Nielsen,Verena Siewers,Yun Chen*. Fine-tuning of p-coumaric acid synthesis to increase (2S)-naringenin production in yeast. Metabolic Engineering,2023,79: 192-202.

Chunjun Zhan#,Xiaowei Li#,Guangxu Lan,Edward EK Baidoo,Yankun Yang,Yuzhong Liu,Yang Sun,Shijie Wang,Yanyan Wang,Guokun Wang,Jens Nielsen*,Jay D Keasling*,Yun Chen*,Zhonghu Bai*. Reprogramming methanol utilization pathways to convert Saccharomyces cerevisiae to a synthetic methylotroph. Nature Catalysis,2023,6(5):435-450.

Xin Chen*,Xiaowei Li,Boyang Ji,Yanyan Wang,Olena P Ishchuk,Egor Vorontsov,Dina Petranovic,Verena Siewers*,Martin KM Engqvist. Suppressors of amyloid-beta toxicity improve recombinant protein production in yeast by reducing oxidative stress and tuning cellular metabolism. Metabolic Engineering,2022,72: 311-324.

Chunjun Zhan,Xiaowei Li,Yankun Yang,Jens Nielsen,Zhonghu Bai*,Yun Chen*. Strategies and challenges with the microbial conversion of methanol to high-value chemicals. Biotechnology and Bioengineering,2021,118(10):3655-3668.

Xiaowei Li,Yanyan Wang,Gang Li,Quanli Liu,Rui Pereira,Yun Chen,Jens Nielsen*. Metabolic network remodelling enhances yeast’s fitness on xylose using aerobic glycolysis. Nature Catalysis,2021,4(9):783-796.

Ning Qin,Lingyun Li,Xu Ji,Xiaowei Li,Yiming Zhang,Christer Larsson,Yun Chen,Jens Nielsen,Zihe Liu*. Rewiring central carbon metabolism ensures increased provision of acetyl-CoA and NADPH required for 3-OH-propionic acid production. ACS Synthetic Biology,2020,9(12):3236-3244.

Xin Chen,Boyang Ji,Xinxin Hao,Xiaowei Li,Frederik Eisele,Thomas Nyström,Dina Petranovic*. FMN reduces Amyloid-bata toxicity in yeast by regulating redox status and cellular metabolism. Nature Communications,2020,11(1):867.

Quanli Liu,Tao Yu,Xiaowei Li,Yu Chen,Kate Campbell,Jens Nielsen,Yun Chen*. Rewiring carbon metabolism in yeast for high level production of aromatic chemicals. Nature communications,2019,10(1):4976.

Yasaman Dabirian#,Xiaowei Li#*,Yun Chen,Florian David,Jens Nielsen,Verena Siewers*. Expanding the dynamic range of a transcription factor-based biosensor in Saccharomyces cerevisiae. ACS Synthetic Biology,2019,8(9):1968-1975.

Xiaowei Li,Yun Chen,Jens Nielsen*. Harnessing xylose pathways for biofuels production. Current opinion in biotechnology,2019,57: 56-65.

Tian Ma,Bin Shi,Ziling Ye,Xiaowei Li,Min Liu,Yun Chen,Jiang Xia,Jens Nielsen,Zixin Deng,Tiangang Liu*. Lipid engineering combined with systematic metabolic engineering of Saccharomyces cerevisiae for high-yield production of lycopene. Metabolic engineering,2019,52: 134-142.

Xiaowei Li,Daoyi Guo,Yongbo Cheng,Fayin Zhu,Zixin Deng,Tiangang Liu*. Overproduction of fatty acids in engineered Saccharomyces cerevisiae. Biotechnology and bioengineering,2014,111(9):1841-1852.