高乐----中国科学院天津工业生物技术研究所

人才队伍

研究员/正高级工程师

高乐

职　　称：研究员
学　　历：博士研究生
导师类别：硕士生导师
通讯地址：天津市空港经济区西七道32号
电　　话：022-24828745
邮政编码：300308
电子邮件：gao_l@tib.cas.cn
部　　门：营养资源生物合成研究组

简历

高乐，研究员，博士，毕业于山东大学，现任中国科学院天津工业生物技术研究所研究员。研究工作通过组学数据发掘毕赤酵母、丝状真菌底盘细胞对一碳甲醇、秸秆等低值原料的高效转化机制，构建了低值原料代谢功能元件库和调控元件库。采用合成生物学技术理性重编程毕赤酵母、丝状真菌代谢网络，精细调配功能元件-途径-底盘的适配性；并结合适应性进化、反向代谢工程的方法提升底盘细胞利用工农业副产品的效能选育高效降解低值原料的工程菌；首创木质纤维素结构特性-酶组分无监督机器学习模型，破译基于木质纤维素结构特点精确求解最佳酶系组成的新算法，逐级突破低值原料利用、蛋白转换的技术瓶颈，创制以功能蛋白/肽、酶、天然产物等功能性营养物质，实现酶/功能蛋白人工创制及在饲用和食品领域精准应用。授权国家发明专利23件，其中成果许可或转化项目8项，以第一作者/通讯作者在Trends Biotechnol, Biotechnol. Adv., Chem. Eng. J, Bioresour. Technol., Crit Rev Biotechnol., J.B.C等国内外公开发表论文40余篇，参与出版英文专著1件；主持国家自然科学基金面上项目、国家重点研发计划课题、政府间国际科技创新合作重点专项课题、天津市科技计划项目、吉林省院合作项目等十余个项目。

研究方向

（1）研发低值原料规模化生物合成微生物蛋白的适配体系及绿色生产工艺，开发功能性饲用/食用蛋白原料，并开展应用关键技术研发与产业化示范。

（2）创制功能性肽、功能蛋白、抗氧化产物等营养物质生物合成的关键技术，并开展应用关键技术研发与产业化示范。

获奖及荣誉

第八届中国创新挑战赛生物制造技术专题赛，优秀奖

代表成果

1. Changyu Pi, Jinyang Li, Tongtong Bao, Le Gao*, Xin Wu*. Integrated base editing and microfluidics boost microbial lipid production from lignin. Bioresource Technology. 2026, 440, 133441.

2. Le Gao*, KS Ching, Zhaokun Zhang, Xin Wu*. Trends in Sustainable Single-Cell Protein from Non-grain Feedstocks. Trends in biotechnology. DOI: 10.1016/j.tibtech.2025.04.018.

3. Le Gao, Jie Yuan, Kai Hong, Xin Wu*. Technological advancement spurs Komagataella phaffii as a next-generation platform for sustainable biomanufacturing. Biotechnology advances. 2025, 82, 108593.

4. Le Gao, Tiantian Zhou, Jie Yuan, Shouchang Zhang, Kai Hong, Zhaokun Zhang, Lee Chia Hau, Wai San Cheang, Chichun Zhou, Xin Wu*. AI-powered de novo architecturing of marine-mimetic antioxidant peptides in yeast synbio factories. Chemical Engineering Journal. 2025, 524, 169604.

5. Jinyang Li, Changyu Pi, Jintong Zhang, Fangting Jiang, Tongtong Bao, Le Gao*, Xin Wu*. Fungal bioconversion of lignin-derived aromatics: Pathways, enzymes, and biotechnological potential. Biotechnology advances. 2025, 83, 108624.

6. Le Gao, Fangting Jiang, Zhaokun Zhang, Tongtong Bao, Daochen Zhu, Xin Wu*. Unlocking lignin valorization and harnessing lignin-based raw materials for bio-manufacturing. Science china life sciences. 2025, 68, 994-1009.

7. Le Gao, Jiajun Sun, Zhaokun Zhang, Xin Wu*. Systems Metabolic Engineering of Phaffia rhodozyma for Ultra-High Astaxanthin Production through Multiple Strategies. Science china life sciences. 2025, doi: 10.1007/s11427-025-3005-3.

8. Fengyun Ren, Fan Wu, Chengyu Jie, Le Gao*, Xin Wu*. Carbon-nitrogen metabolic coupling for optimized protein production of corn stover polysaccharides: From molecular mechanisms to buffalo rumen microbiome. International Journal of Biological Macromolecules. 2025, 320, 145901.

9. Le Gao, Xin Wu*. Biochemical characterization, biosynthesis mechanism, and functional evaluation of selenium-enriched Aspergillus oryzae A02. International Journal of Biological Macromolecules. 2024, 275, 133714.

10. Le Gao, Zhuohang Yu, Shengjie Wang, Yuejie Hou, Shouchang Zhang, Chichun Zhou*, Xin Wu*. A new paradigm in lignocellulolytic enzyme cocktail optimization: Free from expert-level prior knowledge and experimental datasets. Bioresource Technology. 2023, 388,12975.

11. Le Gao, Jiao Meng, Wuling Dai, Zhaokun Zhang, Haofan Dong, Qianqian Yuan, Wuyuan Zhang, Shuguang Liu, Xin Wu*. Deciphering cell wall sensors enabling the construction of robust P. pastoris for single-cell protein production. Biotechnology for Biofuels and Bioproducts. 2023, 16, 178.

12. Le Gao, Yi Jiang, Kai Hong, Xiaoyi Chen*, Xin Wu*. Glycosylation of cellulase: a novel strategy for improving cellulase. Critical Reviews in Biotechnology. 2022, 1:11.