研究员/正高级工程师
郑宏臣

郑宏臣


  • 职  称:正高级工程师
  • 学  历:博士研究生
  • 导师类别:硕士生导师
  • 通讯地址:天津空港经济区西七道32号
  • 电  话:022-84861933
  • 邮政编码:300308
  • 电子邮件:zheng_hc@tib.cas.cn
  • 部  门:生物大分子合成与微生物代谢工程研究组

简历

2025.9-今,中国科学院天津工业生物技术研究所,正高级工程师

2018.11 - 2025.9,中国科学院天津工业生物技术研究所,副研究员

2014.08 - 2018.11,中国科学院天津工业生物技术研究所,助理研究员

2012.10 - 2014.07,农业农村部规划设计研究院,博士后

2009.09 - 2012.10,天津科技大学,发酵工程,工学博士

中国食品科学技术学会酶制剂分会理事,中国微生物学会会员;国际学术期刊International Journal of Biotechnology and Recent Advances (IJBRA)编委;国际学术期刊Bioengineering客座编辑,Biotechnological Advances in Industrial Enzymes and Green Bioprocessing特刊主编;Bioresource TechnologyInternational Journal of Biological Macromolecules Food BioscienceFood & FunctionMicrob Cell FactScientific Reports等国际期刊审稿人。

研究方向

主要研究领域包括工业酶制剂的开发与应用研究,新酶基因挖掘、蛋白质的合成生物学、工业生产菌株(芽孢杆菌为主)的改造与创制、微生物应用技术等。

获奖及荣誉

2016,天津市专利奖优秀奖(排名第3

代表成果

1. Liang H#, Dong W#, Fu X, Zheng H*, Li M*, Bai W*. High-efficiency secretory expression of polyethylene terephthalate hydrolases in Bacillus amyloliquefaciens 205 and complete degradation of PET by its crude enzyme. Int J Biol Macromol. 2025, 330(Pt 2):148111.

2. Qingfang Meng#, Dexin Wang#, Xiaoping Fu, Weitao Geng*, Hongchen Zheng*, and Wenqin Bai*. Converting Bacillus subtilis 168 to a Synthetic Methylotroph by Combinatorial Metabolic Regulation Strategies. Journal of Agricultural and Food Chemistry. 2025, 73(8): 4755-4763.

3. Zhao Xingya, Fu Xiaoping, Zhen Jie, Yang Jun, Zheng Hongchen*, Bai Wenqin*, Song Hui. BsuMI regulates DNA transformation in Bacillus subtilis besides the defense system and the constructed strain with BsuMI absence is applicable as a universal transformation platform for wild-type Bacillus. Microb Cell Fact. 2024, 23: 225.

4. Yifan Yang#, Xiaoping Fu#, Xingya Zhao, Jianyong Xu, Yihan Liu*, Hongchen Zheng*, Wenqin Bai*, Hui Song. Overexpression of a Thermostable α-Amylase through Genome Integration in Bacillus subtilis. Fermentation-Basel. 2023, 9(2):139.

5. Hongchen zheng#,*, Wenju Shu#, Xiaoping Fu#, Xingya Zhao, Shibin Yang, Jianyong Xu*, Hui Song*, Yanhe M. A pyruvate-centered metabolic regulation mechanism for the enhanced expression of exogenous genes in Escherichia coli. Int J Biol Macromol. 2022, 203:58-66.

6. Jie Zhen#, Hongchen Zheng#,*, Xingya Zhao#, Xiaoping Fu, Shibin Yang, Jianyong Xu*, Hui Song*, Yanhe Ma. Regulate the hydrophobic motif to enhance the non-classical secretory expression of Pullulanase PulA in Bacillus subtilis. Int J Biol Macromol. 2021, 193: 238-246.

7. ShiBin Yang#, HongChen Zheng#,*, JianYong Xu, XingYa Zhao, WenJu Shu, XiangMing Li, Hui Song*, YanHe Ma*. A new biotransformation mode of zearalenone identified in Bacillus subtilis Y816 revealing a novel ZEN conjugate. Journal of Agricultural and Food Chemistry. 2021, 69(26): 7409-7419.

8. Zhao X#, Zheng H#,*, Zhen J, Shu W, Yang S, Xu J, Song H*, Ma Y*. Multiplex genetic engineering improves endogenous expression of mesophilic α-amylase gene in a wild strain Bacillus amyloliquefaciens 205. Int J Biol Macromol. 2020, 165(Pt A): 609-618.

9. Zhao X#, Xu J#, Tan M#, Zhen J, Shu W, Yang S, Zheng H*, Ma Y*, Song H*. High copy number and highly stable Escherichia coli-Bacillus subtilis shuttle plasmids based on pWB980. Microb Cell Fact. 2020, 19(1): 25.

10. Zeng Y#, Xu J#, Fu X, Tan M, Liu F, Zheng H*, Song H*. Effects of different carbohydrate-binding modules on the enzymatic properties of pullulanase. Int J Biol Macromol. 2019, 137:973-981.

11. Zheng H#, Yu Z#, Shu W#, Fu X, Zhao X, Yang S, Tan M, Xu J, Liu Y*, Song H*. Ethanol effects on the overexpression of heterologous catalase in Escherichia coli BL21 (DE3). Appl Microbiol Biotechnol. 2019, 103(3): 1441-1453.

12. Zhao X#, Xu J#, Tan M, Yu Z, Yang S, Zheng H*, Song H*. Construction of a plasmid interspecific transfer system in Bacillus species with the counter-selectable marker mazF. J Ind Microbiol Biotechnol. 2018, 45(6):417-428.

13. Yu Z#, Zheng HC#, Zhao X, Li S, Xu J, Song H*. High level extracellular production of a recombinant alkaline catalase in E. coli BL21 under ethanol stress and its application in hydrogen peroxide removal after cotton fabrics bleaching. Bioresour Technol. 2016, 214: 303-310.

14. Zheng Hongchen#, Yihan Liu#, Xiaoguang Liu, Yang Han, Jianling Wang, Fuping Lu*. Overexpression of a Paenibacillus campinasensis xylanase in Bacillus megaterium and its applications to biobleaching of cotton stalk pulp and saccharification of recycled paper sludge. Bioresource Technology. 2012, 125: 182-187.

15. 郑宏臣,徐健勇,杨建花,郑迎迎,涂然,石婷,付刚,刘倩,王兴彪,韩旭,张以恒,柏文琴*,宋诙*.工业酶与绿色生物工艺的核心技术进展. 生物工程学报2022, 3811):4219-4239.