研究员/正高级工程师
王猛

王猛


  • 职  称:研究员
  • 学  历:博士研究生
  • 导师类别:博士生导师
  • 通讯地址:天津空港经济区西七道32号
  • 邮政编码:300308
  • 电子邮件:wangmeng@tib.cas.cn
  • 部  门:高通量编辑与筛选平台实验室

简历

  1、教育经历

  2001.9-2005.7,浙江大学,化学,学士学位

  2001.9-2005.7,浙江大学,生物信息学,第二学位

  2005.8-2009.12 雪城大学(Syracuse University),化学,博士学位

  2、工作经历

  2010.1-2015.4伊利诺伊大学厄巴纳 - 香槟分校(University of Illinois at Urbana-Champaign),博士后

  2015-至今, 中国科学院天津工业生物技术研究所,研究员

研究方向

高通量筛选与编辑平台实验室(王猛组)依托于研究所大型自动化装备,通过对生物学研究操作过程的高通量化与自动化使得人力从繁琐的重复工作中解放出来,同时也通过完成人力不可能完成的大量实验实现从数量到质量的突变,能把生物学研究推向一个新的高峰。国际上高通量筛选从设备到技术远没有达到系统化与标准化,正处于高速发展百家争鸣的阶段。研究组现阶段在高通量筛选平台的工作主要集中于将生物学研究的核心实验操作实现高通量自动化。如实现微生物DNA转化的高通量自动化;质粒库、菌种突变库的高通量自动化构建;菌种的自动化改造,小分子化合物的高通量检测等。另一方面研究组主要运用合成生物学、分子生物学、生物化学及高通量生物技术等手段,开展围绕生物活性分子的发掘、生物合成机理、高效生产为核心问题的基础及应用技术研究。研究成果在Nat Commun, Trends Biotechnol, ACS Catal, Meta Eng等国际一流杂志上发表31篇文章。申请专利6项。

代表成果

1.Lili Chang, Jin Wang, Meng Wang*, Yue Zhang*.(2025) Emerging strategies to develop novel genetically encoded biosensors. Trends Biotechnol, 2025, In press. https://doi.org/10.1016/j.tibtech.2025.04.014

2.Longqian Zhao,Shixin Li,Yi Yang,Linin Qi,Qinyuan Zhu,Yue Zhao,Hui Qi,Xiaoping Liao, Yue Zhang*,Meng Wang*. (2025)Biosensor-based dual-color droplet microfluidic platform for precise high-throughput screening of erythromycin hyperproducers. Biosens Bioelectron. 2025 Jun 15;278:117376. doi: 10.1016/j.bios.2025.117376. Epub 2025 Mar 13. PMID: 40090258.

3.Jiao Liu, Xiaojia Zhao, Haijiao Cheng, Yanmei Guo, Xiaomeng Ni, Lixian Wang, Guannan Sun, Xiao Wen, Jiuzhou Chen, Jin Wang, Jingjing An, Xuan Guo, Yu Wang*, Ping Zheng1*, Meng Wang*, Jibin Sun. (2025).Comprehensive screening of industrially relevant components at genome scale using a high-quality gene overexpression collection of Corynebacterium glutamicum,Trends Biotechnol. 2025 Jan;43(1):220-247. doi: 10.1016/j.tibtech.2024.09.020. Epub 2024 Oct 24. PMID: 39455323.

4.Jin Wang , Ning Xue, Wenjia Pan, Ran Tu , Shixin Li, Yue Zhang, Yufeng Mao, Ye Liu, Haijiao Cheng, Yanmei Guo, Wei Yuan, Xiaomeng Ni, Meng Wang*. (2023) Repurposing conformational changes in ANL superfamily enzymes to rapidly generate biosensors for organic and amino acids. Nat Commun.14(1):6680

5.Yang Liu, Haijiao Cheng, Haoni Li, Yingzhe Zhang, Meng Wang*. (2023) A programmable CRISPR/Cas9 toolkit improves lycopene production in Bacillus subtilis. Appl Environ Microbiol.

6.Yue Zhang*Xuemei Zhang, Meng Wang*(2023Product-driven high-throughput screening of industrial filamentous actinomycetesTrends Biotechnol, 41(9):1109-1112

7.Wei Yuan, Chenjian Jiang, Qin Wang, Yubo Fang, Jin WangMeng Wang *, Han Xiao *Biosynthesis of mushroom-derived type II ganoderic acids by engineered yeast(2022Nat Commun. 13(1):7740

8.Siwei Li, Jingjing An, Yaqiu Li, Xiagu Zhu, Dongdong Zhao, Lixian Wang, Yonghui Sun, Yuanzhao Yang, Changhao Bi*, Xueli Zhang* & Meng Wang*, Automated high-throughput genome editing platform with an AI learning in situ prediction model. (2022), Nat Commun 13(1):7386

9.Ye Liu, Ruoyu Wang, Jiahui Liu, Hui Lu, Haoran Li, Yu Wang, Xiaomeng Ni, Junwei Li, Yanmei Guo, Hongwu Ma, Xiaoping Liao*, Meng Wang*(2022) Base editor enables rational genome-scale functional screening for enhanced industrial phenotypes in Corynebacterium glutamicumSci Adv8(35):eabq2157

10.Ran Tu, Yue Zhang, Erbing Hua, Likuan Bai, Huamei Huang, Kaiyue Yun, Meng Wang*,(2021) Droplet-based microfluidic platform for high-throughput screening of Streptomyces. Commun Biol, 31;4(1):647

11.Yu Wang*, Haijiao Cheng, Yang Liu, Ye Liu, Xiao Wen, Kun Zhang, Xiaomeng Ni, Ning Gao, Liwen Fan, Zhihui Zhang, Jiao Liu, Jiuzhou Chen, Lixian Wang, Yanmei Guo, Ping Zheng*, Meng Wang*, Jibin Sun and Yanhe Ma(2021) In-situ generation of large numbers of genetic combinations for metabolic reprogramming via CRISPR-guided base editing. Nat Commun, 12(1):678.

12.Yu Wang*, Ye Liu, Ping Zheng, Jibin Sun and Meng Wang*,(2020) Microbial Base Editing: A Powerful Emerging Technology for Microbial Genome Engineering. Trends Biotechnol, 39(2):165-180

13.Xiaoting Lan, Wei Yuan, Meng Wang*, Han Xiao*. (2019). Efficient biosynthesis of antitumor ganoderic acid HLDOA using a dual tunable system for optimizing the expression of CYP5150L8 and a Ganoderma P450 reductase. Biotechnol Bioeng 116(12):3301-3311

14.Han Xiao*, Yue Zhang#, Meng Wang*2018Discovery and engineering of cytochrome P450s for terpenoid biosynthesisTrends Biotechnol. pii: S0167-7799(18)30318-4

15.Yu W, Ye L, Jiao L, Yanmei G, Liwen F, Xiaomeng N, Xiaomei Z , Meng W*, Ping Z*, Jibin S*, Yanhe M2018MACBETH: multiplex automated Corynebacterium glutamicum base editing method. Metabolic Engineering. May 47:200-210