李志超
工作定位于应用基础研究,以生物合成底盘及底层分子使能技术为研究开发对象,服务于合成生物学。主要以高等植物、藻类、模式底盘微生物等为研究材料,开发多种基因组(细胞核、叶绿体、线粒体)转化、编辑、转移融合等基因工程技术并以此构建新型的生物合成底盘。具体从事解析水平基因转移(天然转基因)进化事件的分子机制,借此开发全新高效的基因递送及表达调控、基因组转移、融合、扩增等基因工程及合成生物学使能技术;并以此构建包括植物悬浮细胞、创新微生物等新型的生物合成底盘和细胞工厂,对传统微生物底盘合成困难的高值产品(如植物天然产物)进行高效生物合成。
中国科学院人才引进计划择优支持
2. Zhu X, Liu X, Liu T, Wang Y, Ahmed N, Li ZC*, Jiang HF* (2021) Synthetic biology of plant natural products: From pathway elucidation to engineered biosynthesis in plant cells. Plant Communications 2, 100229.
3. Li ZC, Bock R (2019) Rapid functional activation of a horizontally transferred eukaryotic gene in a bacterial genome in the absence of selection. Nucleic Acids Research (IF: 11.561) doi: 10.1093/nar/gkz370.
4. Li ZC, Bock R (2018) Replication of bacterial plasmids in the nucleus of the red alga Porphyridium purpureum. Nature Communications (IF: 12.353) 9, 3451.
5. Li ZC, He CY. (2015) Physalis floridana Cell Number Regulator1 encodes a cell membrane-anchored modulator of cell cycle and negatively controls fruit size. Journal of Experimental Botany (IF: 5.354) 66, 257–270.
6. Zhang JS#, Li ZC#, Zhao J, Zhang SH, Quan H, Zhao M, He CY (2014) Deciphering the Physalis floridana Double-Layered-Lantern1 mutant provides insights into functional divergence of theGLOBOSAduplicates within the Solanaceae. Plant Physiology (IF: 5.949) 164, 748–764. (#:共同一作)
7. Wang L, He LL, Li J, Zhao J, Li ZC, He CY (2014) Regulatory change at Physalis Organ Size 1 locus correlates to natural variation in tomatillo reproductive organ size. Nature Communications 5, 4271.
8. Wang L, Li ZC, He CY (2012) Transcriptome-wide mining of the differently expressed transcripts for natural variation of floral organ size in Physalis philadelphica. Journal of Experimental Botany 63, 6457–6465.
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