张玲玲----中国科学院天津工业生物技术研究所

人才队伍

研究员/正高级工程师

张玲玲

职　　称：研究员
学　　历：博士研究生
导师类别：博士生导师
通讯地址：天津市空港经济区西七道32号
电　　话：022-84866448
邮政编码：300308
电子邮件：zhangll@tib.cas.cn
部　　门：体外合成生物学中心

简历

2006. 09 – 2010. 06 武汉大学化学生物学专业理学学士

2010. 09 – 2016. 01 中国科学院长春应用化学研究所分析化学专业硕博连读理学博士

2016. 02 – 2016. 03 中国科学院长春应用化学研究所电分析国家重点实验室助理研究员

2016. 04 – 2017. 02 丹麦奥胡斯大学 iNANO中心生物电催化课题组博士后

2017. 04 – 2020. 07 德国亚琛工业大学生物技术所博士后/洪堡学者

2020. 09 – 至今中国科学院天津工业生物技术研究所体外合成生物学中心研究员

研究方向

以酶的电催化为研究核心，涉及研究方向包括：

电能辅助二氧化碳生物转化利用
电驱动ATP再生系统的设计与创建
生物电化学传感、生物燃料电池、体外生物电合成体系的设计与应用
酶电催化导向的酶分子改造
酶-电极相互作用分子机制研究及酶定向固定工具开发

代表成果

刘伟松，张坤城，崔会娟，朱之光，张以恒，张玲玲*. 电能辅助二氧化碳生物转化.合成生物学，2023，4. DOI：10.12211/2096-8280.2023-041
Hongyu Chen, Weisong Liu, Lijing Chang, Zepeng Kang, Yanqin Yang*, Lingling Zhang*, Tailoring Galactose Oxidase for Self-powered Benzyl Alcohol Sensing, Chem. Eur. J. 2023, DOI: 10.1002/chem.202300052.
Huijuan Cui, Weisong Liu, Chunling Ma, Pezhman Shiri, Huifeng Jiang, Demao Li*, Lingling Zhang*, Converting CO₂ to single-cell protein via an integrated electrocatalytic-biosynthetic system, in submission
Lijing Chang, Huijuan Cui, Fei Li, Lingling Zhang*, ATP regeneration by ATPases for in vitro Biotransformation, in submission
Weisong Liu, Yuanming Wang, Meixia Liu, Kuncheng Zhang, Meng Zhang, Junsong Sun, Yi-Heng P. Job Zhang, Lingling Zhang*, Heterologous expression and rational engineering of anaerobic formate dehydrogenase from Thermoanaerobacter Kivui for high-efficient bioelectrocatalytic CO₂ reduction, in submission
Lijing Chang, Yi-Heng P. Job Zhang, Tao Cai, Lingling Zhang*, Electro-driven phosphorylation for in vitro biotransformation via constructing an ATPase artificial membrane, in submission
Meng Zhang, Weisong Liu, Kuncheng Zhang, Qingxiu Wang, Xuan Wang, Lingling Zhang*, Engineering an affinity peptide for robust immobilization and orientation of laccases, in submission
Haiyang Cui, Lingling Zhang*, Dominik Söder, Xiaomei Tang, Mehdi D. Davari, and Ulrich Schwaneberg*, Rapid and Oriented Immobilization of Laccases on Electrodes via a Methionine-Rich Peptide, ACS Catal. 2021, 11, 2445-2453.
Lingling Zhang*, Haiyang Cui, Gaurao V. Dhoke, Zhi Zou, Daniel F. Sauer, Mehdi D. Davari, and Ulrich Schwaneberg*, Engineering of Laccase CueO for Improved Electron Transfer in Bioelectrocatalysis by Semi-rational Design, Chem. Eur. J. 2020, 26, 4974-4979.
Lingling Zhang*, Haiyang Cui, Zhi Zou, Tayebeh Mirzaeigarakani, Catalina Novoa-Henriquez, Bahareh Jooyeh, Ulrich Schwaneberg*, Directed Evolution of a Bacterial Laccase (CueO) for Enzymatic Biofuel Cells, Angew. Chem. Int. Ed. 2019, 131, 4562-4565.