崔成森----中国科学院天津工业生物技术研究所

人才队伍

研究员/正高级工程师

崔成森

职　　称：研究员
学　　历：博士研究生
导师类别：博士生导师
通讯地址：天津市空港经济区西七道32号
邮政编码：300308
电子邮件：cuichs@tib.cas.cn
部　　门：药物化学与生物合成研究组

简历

2022-至今，中国科学院天津工业生物技术研究所，研究员

2018-2021年，美国普渡大学化学与癌症研究中心，博士后

2017-2018年，美国哈佛大学化学与化学生物学系，博士后

2015-2017年，香港科技大学化学系，助理研究员

2011-2015年，英国布里斯托大学，博士

2007-2011年，西北农林科技大学，学士

研究方向

主要研究方向为挖掘并改造天然产物生物合成途径中的酶分子，通过理性设计赋予其高转化率、高区域和立体选择性。开发以人工酶介导的新颖酶促反应，发展化学-酶法药物分子的绿色、可持续、高效的合成新路线，并积极推进产业化。

获奖及荣誉

天津市青年英才

代表成果

参与合成的目标分子

18. Shen,Q.;Yan,J.;Zhang,Z.;Li,H.;Kong,D.;Han,X.;Shi,J.;Cui,C.;* Zhang,W.* Peroxygenase-catalyzed kinetic resolution of racemic hydroperoxides.Manuscript submitted.

17. Li,H.;Duan,P.;Huang,Y.;Cui,C.;Hollmann,F.;Ma,Y.;Wang,Y.;Zhang,W. * Chemoenzymatic Valorisation of Lignin-Derived Phenols and Phenolic Acids. ACS Catal.,2023,Under review.

16. Cui,C.;Dai,M.* Total Synthesis ofUCS1025A via Tandem Carbonylative Stills Cross Coupling and Diels-Alder Reaction. Chin. J. Chem. 2023,41,3019-3024. (Invited contribution dedicated to the Special Issue of C1 Chemistry).

15. Zhu,F.;‡ Zhang,J.;‡ Ma,Y.;Yang,L.;Gao,Q.;Gao,S.-S.;* Cui,C.* Semi-rational design of an imine reductase for asymmetric synthesis of alkylated S-4-azepanamines. Org. Biomol. Chem.,2023,21,4181-4184.

14. Zhang,J.;‡ Ma,Y.;‡ Zhu,F.;‡ Bao,J.;Gao,S.-S.;* Cui,C.* Structure-guide rational design of an imine reductase for enantio-complementary synthesis of pyrrolidinamine. Chem. Sci.,2023,14,4265-4272.

Featured as an Outside Cover;Highlighted by TIB news.

13. Ma,Y.;Yan,J.;Yang,L.;Yao,Y.;Wang,L.;* Gao,S.-S.;* Cui,C.* A Hybrid System for the Overproduction of Complex Ergot Alkaloid Chanoclavine. Front. Bioeng. Biotechnol.,2022,10,2386.

12. Li,J.;Qu,G.;Li,X.;Tian,Y.;Cui,C.;Zhang,F.;Zhang,W.;Ma,J.;* Reetz,M.;* Sun,Z.* Rational enzyme design for enabling biocatalytic Baldwin cyclization and asymmetric synthesis of chiral heterocycles. Nat. Commun.,2022,13,7813.

11. Zhang,J.;Li,X.;Chen,R.;Tan,X.;Liu,X.;Ma,Y.;Zhu,F.;An,C.;Wei,G.;Yao,Y.;Yang,L.;Zhang,P.;Wu,Q.;Sun,Z.;Wang,B.-G.;* Gao,S.-S.;* Cui,C.* Actinomycetes-derived imine reductases with a preference towards bulky amine substrates. Commun. Chem.,2022,5,123.

10. Yu,Z.-P.;An,C.;Yao,Y.;Wang,C.-Y.;Sun,Z.;Cui,C.;Liu,L.;* Gao,S-S* A combined strategy for the overproduction of complex ergot alkaloid agroclavine. Synthetic and Systems Biotechnology,2022,7,1126-1132.

9. Zhang,J.;Liao,D.;Chen,R.;Zhu,F.;Ma,Y.;Gao,L.;Qu,G.;Cui,C.;Sun,Z.;* Lei,X.;* Gao,S.* Tuning Imine Reductase for Asymmetric Synthesis of Azacycloalkylamines by Concise Structure-Guided Engineering. Angew. Chem. Int. Ed.,2022,e202201908.

8. Li,H.;Younes,S. H. H.;Chen,S.;Duan,P.;* Cui,C.;Ron Wever,R.;Zhang,W.;* Hollmann,F.;* A chemoenzymatic Hunsdiecker-type decarboxylative bromination of cinnamic acids. ACS Catal.,2022,12,4554-4559.

7. Cui,C.;‡ Dwyer,B. G.;‡ Liu,C.;Abegg,D.;Yin,X.;Hoch,D.;Cai,Z.;Qiu,N.;Liu,J.;Adibekian,A.;Dai,M.* Total synthesis and chemoproteomics connect curcusone diterpenes with oncogenic protein BRAT 1. J. Am. Chem Soc.,2021,143,4379-4386.

Featured in Purdue News,ScienceDaily,NSF Research News,and others;Highlighted by X-MOL and Synfacts.

6. Wang,Y.;‡ Cui,C.;‡ Dai,M.* Flow Chemistry-Enabled Divergent and Enantioselective Total Syntheses of Massarinolin A,Purpurolides B,D,E,2,3-Deoxypurpurolide C,and Structural Revision of Massarinolin A. Angew. Chem. Int. Ed.,2021,60,24828-24832.

Selected as a Hot Paper;Featured as an Inside Cover;Highlighted by WileyChem

5. H. Raffa,N.;Won,T. H.;Sukowaty,A.;Candor,K.;Cui,C.;Halder,S.;Dai,M.;* Figueroa,J. A. L.;Schroeder,F. C.;Keller,N. P.* Dual-purpose isocyanides produced by Aspergillus fumigatus contribute to cellular copper suffiency and exhibit antimicrobial activity. Proc. Natl. Acad. Sci.,USA,2021,118,e2015224118.

4. Cui,C.;Dai,W.-M.* Total synthesis of laingolide B stereoisomers and assignment of absolute configuration. Org. Lett.,2018,20,3358-3361.

3. Thistlethwaite,I. R. G.;Bull,F. M.;Cui,C.;Walker,P. D.;Gao S.-S.;Wang,L.;Song Z.;Masschelein,J.;Lavigne,R.;Crump,M. P.;Race,P. R.;Simpson,T. J.;and Wills,C. L.* Elucidation of the relative and absolute stereochemistry of the Kalimantacin/batumin antioiotics. Chem. Sci.,2017,8,6196-6201.

2. Shi,J.;Wu,J.;Cui,C.;Dai,W.-M.* Microwave-Assisted intramolecular Ullmann diaryl etherification as the Post-Ugi annulation for generation of dibenz[b,f][1,4]oxazepine scaffold. J. Org. Chem.,2016,81,10392-10403.

1. Zhang,J.*;Cui,C.;Chen,H.;Liu,J. The completion of esterification of free fatty acids in Zanthoxylum bungeanum seed oil with ethanol. International Journal of Green Energy,2014,11,822-832.

申请或授权专利：

1. Dai,M.;Cui,C.;Cai,Z.;Adibekian,A.,Dwyer,B. G. Curcusone diterpenoids and uses thereof.US20230250042A1.

2. 高书山;张军;崔成森;马亚卿;朱芳芳，还原胺化酶突变体及其在烷基化吡咯烷手性胺合成中的应用, CN202310233977.7.