王钰
1、教育经历
2012.09-2016.03,上海交通大学生命科学技术学院,博士研究生,生物学,理学博士
2015.09-2015.10,德国汉堡工业大学,交流访问
2009.09-2012.06,山东大学生命科学学院,硕士研究生,微生物学,理学硕士
2005.09-2009.06,山东大学生命科学学院,本科,生物技术,理学学士
2、工作经历
2022.06-至今,中国科学院天津工业生物技术研究所,研究员
2018.11-2022.06,中国科学院天津工业生物技术研究所,副研究员
2016.04-2018.11,中国科学院天津工业生物技术研究所,助理研究员
1.Liu J, Liu M, Shi T, Sun G, Gao N, Zhao X, Guo X, Ni X, Yuan Q, Feng J, Liu Z, Guo Y, Chen J, Wang Y*, Zheng P*, Sun J. 2022. CRISPR-assisted rational flux-tuning and arrayed CRISPRi screening of an L-proline exporter for L-proline hyperproduction. Nat Commun, 13, 891 (Editors’ highlights and Focus article on biotechnology and method).
2.Wang Y, Zhao D, Sun L, Wang J, Fan L, Cheng G, Zhang Z, Ni X, Feng J, Wang M, Zheng P*, Bi C*, Zhang X*, Sun J. 2022. Engineering of the translesion DNA synthesis pathway enables controllable C-to-G and C-to-A base editing in Corynebacterium glutamicum. ACS Synth Biol, 11, 3368–3378.
3.Chen J, Wang Y*, Zheng P*, Sun J. 2022. Engineering synthetic auxotrophs for growth-coupled directed protein evolution. Trends Biotechnol, 40, 773–776.
4.Wang Y*, Zheng P, Sun J*. 2022. Developing synthetic methylotrophs by metabolic engineering-guided adaptive laboratory evolution. Adv Biochem Eng Biotechnol, 180, 127–148.
5.Zhou W, Fu G, Qi X, Zheng X, Fang H, Xia M, Zhang D, Wang Q, Zheng P, Wang Y*, Sun J. 2022. Upgrading microbial strains for fermentation industry. Chin J Biotech, 38, 1–19.
6.Wang Y*, Cheng H, Liu Y, Liu Y, Wen X, Zhang K, Ni X, Gao N, Fan L, Zhang Z, Liu J, Chen J, Wang L, Guo Y, Zheng P*, Wang M*, Sun J, Ma Y. 2021. In-situ generation of large numbers of genetic combinations for metabolic reprogramming via CRISPR-guided base editing. Nat Commun, 12, 678 (Editors’ highlights and Focus article on biotechnology and method).
7.Wang Y*, Liu Y, Zheng P, Sun J, Wang M*. 2021. Microbial base editing: a powerful emerging technology for microbial genome engineering. Trends Biotechnol, 39, 165–180 (Selected cover and free featured article).
8.Zhang Z, Wang Y*, Zheng P*, Sun J. 2021. Promoting lignin valorization by coping with toxic C1 byproducts. Trends Biotechnol, 39, 331–335.
9.Wang Y, Fan L, Tuyishime P, Liu J, Zhang K, Gao N, Zhang Z, Ni X, Feng J, Yuan Q, Ma H, Zheng P*, Sun J*, Ma Y. 2020. Adaptive laboratory evolution enhances methanol tolerance and conversion in engineered Corynebacterium glutamicum. Commun Biol, 3:217 (Springer Nature high impact publications by Chinese researchers).
10.Wang Y, Fan L, Tuyishime P, Zheng P*, Sun J*. 2020. Synthetic methylotrophy: a practical solution for methanol-based biomanufacturing. Trends Biotechnol, 38, 650–666.
11.Wang Y, Liu Y, Li J, Yang Y, Ni X, Cheng H, Huang T, Guo Y, Ma H, Zheng P*, Wang M*, Sun J, Ma Y. 2019. Expanding targeting scope, editing window, and base transition capability of base editing in Corynebacterium glutamicum. Biotechnol Bioeng, 116:3016–3029 (Selected cover article).
12.Wang Y, Liu Y, Liu J, Guo Y, Fan L, Ni X, Zheng X, Wang M*, Zheng P*, Sun J*, Ma Y. 2018. MACBETH: multiplex automated Corynebacterium glutamicum base editing method. Metab Eng, 47:200–210.
13.Wang Y, Cao G, Xu D, Fan L, Wu X, Ni X, Zhao S, Zheng P*, Sun J*, Ma Y. 2018. A novel Corynebacterium glutamicum L-glutamate exporter. Appl Environ Microbiol, 84:e02691-17.
14.Tuyishime P#, Wang Y#, Fan L, Zhang Q, Li Q, Zheng P*, Sun J*, Ma Y. 2018. Engineering Corynebacterium glutamicum for methanol-dependent growth and glutamate production. Metab Eng, 49:220–231.
15.Wang Y, Tao F, Xin B, Liu H, Gao Y, Zhou NY, Xu P*. 2017. Switch of metabolic status: redirecting metabolic flux for acetoin production from glycerol by activating a silent glycerol catabolism pathway. Metab Eng, 39:90–101.
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