以第一作者/通讯作者在P Natl Acad Sci USA、J Am Chem Soc、Nat Commun、Green Chem等学术期刊上发表研究论文，相关文章及授权专利近30篇/项。

代表性成果：

1. Han Liu^#, Tianwen Shang^#, Scott Mazurkewich^#, Zhidan Zhang, Junpeng Hu, Tao Cai, Xuegang Luo, Dongyuan Zhang, Leli Wang, Yulong Yin*, Yuanxia Sun*, Johan Larsbrink, Christophe Chipot, and Zhiyou Zong* Cyclization Decoded: Engineering Amylomaltase for Efficient α‑Glucan Transformations. J Am Chem Soc, 2025, 147, 33162.

2. Zhiyou Zong*, Xuewen Zhang, Peng Chen, Zhuoyue Fu, Yan Zeng, Qian Wang, Christophe Chipot, Leila Lo Leggio & Yuanxia Sun* Elucidation of the noncovalent interactions driving enzyme activity guides branching enzyme engineering for α-glucan modification. Nat. Commun, 2024, 15, 8760.

3. Han Liu, Yu Ding, Scott Mazurkewich, Wenwen Pei, Xiuxin Wei, Johan Larsbrink, Christophe Chipot*, Zhangyong Hong*, Wensheng Cai* and Zhiyou Zong* Boosting Enzyme Activity in Biomass Conversion by Modulating the Hydrolysis Process of Cellobiohydrolases. ACS Catal, 2024, 14, 16044.

4. Zhiyou Zong, Xinzhuo Liu, Zhuo Ye, Dingbin Liu* A double-switch pHLIP system enables selective enrichment and identification of circulating tumor-derived extracellular vesicles.P Natl Acad Sci USA, 2023, 120, e2214912120.

5. Zhiyou Zong, Scott Mazurkewich, Caroline S. Pereira, Haohao Fu, Wensheng Cai, Xueguang Shao, Munir S. Skaf, Johan Larsbrink, Leila Lo Leggio* Mechanism and biomass association of glucuronoyl esterase: an α/β hydrolase with potential in biomass conversion. Nat Commun, 2022, 13(1): 1-10.

6. Zhiyou Zong, Qiyu Li, Zhangyong Hong, Haohao Fu, Wensheng Cai*, Christophe Chipot, Huifeng Jiang, Dongyuan Zhang, Shulin Chen and Xueguang Shao*. Lysine mutation of the claw-arm-like loop accelerates catalysis by cellobiohydrolases. J Am Chem Soc, 2019, 141, 14451-14459.

7. Zhiyou Zong, Ronglin He, Haohao Fu, Tanfeng Zhao, Shulin Chen, Xueguang Shao and Wensheng Cai* Pretreating cellulases with hydrophobins for improving bioconversion of cellulose: an experimental and computational study. Green Chem, 2016, 18: 6666-6674.

8. Zhiyou Zong, Le Gao, Wensheng Cai, Liang Yu, Chao Cui, Shulin Chen and Dongyuan Zhang* Computer-assisted rational modifications to improve the thermostability of β-glucosidase from Penicillium piceum H16. BioEnerg Res, 2015, 8: 1384-1390.

9. Zhiyou Zong, Lijuan Ma, Liang Yu, Dongyuan Zhang, Zhenhua Yang, Shulin Chen* Characterization of the interactions between polyethylene glycol and cellulase during the hydrolysis of lignocellulose. BioEnerg Res, 2015, 8: 270-278.

10. Yawen Huang, Jie Zhang, Fuqiang Chen, Yu Fu, Han Liu, Zhiyou Zong,* Quanshun Li, Yalan Zhang, Huanhuan Li, Xiang Sheng, Weidong Liu,* and Wuyuan Zhang* Engineering the Fungal Peroxygenase for Efficient and Regioselective Hydroxylation of Vitamin Ds and Sterols. ACS Catal, 2025, 15: 1952−1960.

11. Mohamed Yassin Ali^#, Han Liu^#, Zhenghao Zhang, Jiayue Gao, Sivasamy Sethupathy, Mohamed Fawzy Ramadan, Zhiyou Zong* & Daochen Zhu* Development of SpyTag/SpyCatcher-driven thermostable cyclic laccase and its application in lignin and dye degradation and polymerization of phenolic compounds. Sci China Life Sci, 2025, https://doi.org/10.1007/s11427-024-2836-y.

授权专利：

1. 宗志友，耿坤，刘涵，王芝颖，裂解性多糖单加氧酶突变体及纤维素协同水解方法，中国发明专利，ZL202511293250.3

2. 宗志友，耿坤，刘涵，王芝颖，裂解性多糖单加氧酶突变体及纤维素协同水解方法，中国发明专利，ZL202511293296.5

3. 宗志友，刘定斌，叶卓，刘昕倬，一种用于富集肿瘤微环境来源胞外囊泡的双开关突变体多肽，中国发明专利，ZL202211531758.9

4. 宗志友，马立娟，李晨，张东远，陈树林，一种提高纤维素酶对木质纤维素的酶解效率的方法，中国发明专利，ZL201310313584.3

5. 宗志友，马立娟，赫荣琳，李晨，贾文娣，陈树林，一种从微生物发酵液中提取纤维素酶的方法，中国发明专利，ZL201210412975.6

6. 宗志友，张东远，高乐，王国坤，李晨，崔超，陈树林，一种β-葡萄糖苷酶和β-葡萄糖苷酶突变体及应用，中国发明专利，ZL201410602338.4

7. 蔡文生，宗志友，邵学广，纤维二糖水解酶突变体及其生产方法和应用，中国发明专利，ZL201811340287.7

8. 蔡文生，宗志友，邵学广，纤维二糖水解酶突变体及其应用，中国发明专利，ZL201711049170.9

9. 张东远，宗志友，高乐，王国坤，李晨，崔超，陈树林一种β-葡萄糖苷酶和β-葡萄糖苷酶突变体及应用，，ZL201410603781.3

10. 陈树林，张粲，宗志友，贾文娣，赫荣琳，武改红，李晨，张东远，一株产纤维素酶菌株及其应用，中国发明专利，ZL201410573432.1