2008.09-2012.06  河北大学 生命科学学院 生物科学专业，学士；

2012.09-2015.06  河北大学 生命科学学院 生物化学与分子生物学专业，硕士；

2015.09-2019.06  中国科学院微生物研究所，博士

2019.06-2023.12  中国科学院天津工业生物技术研究所，博士后

2023.12-今       中国科学院天津工业生物技术研究所，副研究员

维生素生物合成，微生物细胞工厂，微生物代谢工程，合成生物技术，发酵工程

1. 论文

1. Lijuan Wu, Jinlong Li, Yahui Zhang, Zhizhong Tian, Zhaoxia Jin*, Linxia Liu *, Dawei Zhang. Multiple Cofactor Engineering Strategies to Enhance Pyridoxine Production in Escherichia coli[J]. Microorganisms. 2024, 12, 933.

2. Zhizhong Tian^#, Linxia Liu^#, Lijuan Wu, Zixuan Yang, Yahui Zhang, Liping Du*, Dawei Zhang*. Enhancement of vitamin B6 production driven by omics analysis combined with fermentation optimization[J]. Microbial Cell Factories. 2024, 3:137.

3. Kai Chen^#, Linxia Liu^#, Jinlong Li^#, Zhizhong Tian, Hongxing Jin*, Dawei Zhang*. Engineering and finetuning expression of SerC for balanced metabolic flux in vitamin B6 production[J]. Synthetic and Systems Biotechnology. 2024, 9: 388–398.

4. Linxia Liu^#, Jinlong Li^#, Yuanming Gai^#, Zhizhong Tian, Yanyan Wang, TengheWang, Pi Liu, Qianqian Yuan, Hongwu Ma, Sang Yup Lee*, Dawei Zhang*. Protein engineering and iterative multimodule optimization for vitamin B₆ production in Escherichia coli[J]. Nature Communications. 2023, 14:5304.

5. Lijuan Wu^#, Linxia Liu^#, Zhaoxia Jin*, Dawei Zhang*. Advances and prospects in the biosynthesis of vitamin B6 and its bioengineering as a cofactor of other chemicals [J]. Food Bioengineering. 2022, 1:171–181.

6. Yanyan Wang^#, Linxia Liu^#, Zhaoxia Jin* and Dawei Zhang*. Microbial cell factories for green production of vitamins[J]. Frontiers in Bioengineering and Biotechnology. 2021, 9:661562.

7. Zimeng Zhang¹, Linxia Liu¹, Chuan Liu, Yumei Sun* and Dawei Zhang*. New aspects of microbial vitamin K2 production by expanding the product spectrum [J]. Microbial Cell Factories. 2021, 20:84.

8. Pengjie Hu^#, Linxia Liu^#, Weixin Ke, Xiuyun Tian, Linqi Wang*. A cyclin protein governs the infectious and sexual life cycles of Cryptococcus neoformans [J]. SCIENCE CHINA Life Sciences. 2021, 64 (8): 1336–1345.

9. Wang YY, Liu LX, Jin ZX, Zhang DW*. Advances in metabolic engineering for vitamins production [J]. Chin J Biotech, 2021, 37(5):1748-1770.

10. Zhu Li, Dongqin Ding, Huiying Wang, Linxia Liu, Huan Fang, Tao Chen, Dawei Zhang*.Engineering Escherichia coli to improve tryptophan production via genetic manipulation of precursor and cofactor pathways [J]. Synthetic and Systems Biotechnology, 2020, 5: 200–205.

11. Linxia Liu^#, Guang-Jun He^#, Lei Chen^#, Jiao Zheng, Yingying Chen, Lan Shen, Xiuyun Tian, Erwei Li, Ence Yang, Guojian Liao, Linqi Wang*. Genetic basis for coordination of meiosis and sexual structure maturation in Cryptococcus neoformans [J]. eLife. 2018, 7: e38683.

12. Qiangyi Wang, Minghao Du, Shuai Wang, Linxia Liu, Liming Xiao, Linqi Wang, Tong Li*, Hui Zhuang* and Ence Yang*. MADS-Box transcription factor MadsA regulates dimorphic transition, conidiation, and germination of Talaromyces marneffei [J]. Frontiers in Microbiology. 2018, 9:1781.

13. Pei-Yao Wei, Lin-Xia Liu, Ting Liu, Chuan Chen, Du-Qiang Luo*, Bao-Zhong Shi. Three new pigment protein tyrosine phosphatases inhibitors from the insect parasite fungus Cordyceps gracilioides: terreusinone A, pinophilin C and cryptosporioptide A[J]. Molecules, 2015, 20: 5825-5834.

14. Linxia Liu^#, Jun Zhang^#, Chuan Chen, Jitao Teng, Chengshu Wang*, Duqiang Luo*. Structure and Biosynthesis of Fumosorinone, a New Protein Tyrosine Phosphatase 1B Inhibitor Firstly Isolated from the Entomogenous Fungus Isaria fumosorosea [J]. Fungal Genetics and Biology. 2015, 81:191-200.

2. 专利

1. 张大伟，刘林霞，王岩岩; 一种生产维生素B6的代谢工程菌株及其构建方法与应用，2021-1-18，中国，ZL202110059483.2。

2. 张大伟，刘林霞，王岩岩，李金龙；磷酸吡哆醇合酶PdxJ突变体及其在制备维生素B6中的应用，2022-4-8，中国，ZL202210360347.1

3.张大伟，刘林霞，王岩岩，李金龙，田治中；4-磷酸羟基-L-苏氨酸脱氢酶PdxA突变体及其在制备维生素B6中的应用，CN114657159B，2022-05-24。

4.张大伟,刘林霞,陈凯,田治中；一种磷酸丝氨酸转氨酶SerC突变体及其构建维生素B6生产菌株的方法，202310145384.5，2023-02-21。

5.张大伟,刘林霞,吴丽娟；一种 4-磷酸羟基-L-苏氨酸脱氢酶突变体及其在构建维生素 B6 生产工程菌中的应用，202410443221X，2024-04-12。