学习经历：

2003.09 -2007.06，天津理工大学，生物工程，学士

2007.09 -2010.03，天津理工大学，药物化学，硕士

工作经历：

2010.10 -2022.06，中国科学院天津工业生物技术研究所，结构生物学与蛋白酶学实验室，助理研究员

2022.07 -2024.09，中国科学院天津工业生物技术研究所，结构生物学平台实验室，工程师

2024.09 - 今，中国科学院天津工业生物技术研究所，结构生物学平台实验室，高级工程师

负责结构生物学平台结构生物学样品制备模块管理及服务工作，从事相关工作十余年，擅长蛋白质制备、蛋白质结晶筛选优化以及蛋白质结构解析等相关的技术服务和方法开发。主持1项国家自然青年基金，并参与多个项目。为多个机构及课题组提供蛋白质制备及蛋白质结构解析全流程服务，已主持或辅助完成几百个结构生物学样品制备，解析获得蛋白质结构30余个。在PLOS Pathogens、Acs Catalysis等期刊参与发表多篇SCI文章,影响因子近60。

（1）蛋白质结构生物学样品的筛选及优化：可溶蛋白、厌氧蛋白、膜蛋白的大规模纯化制备；电镜样品的制备及数据收集。

（2）蛋白质的结构解析：包括缩醛酶、P450酶、六磷酸合酶、糖磷酸异构酶、转氨酶、限制性内切酶、脱氢酶等的结构解析。

（1）Na, Shang; Qian,,Li; Tzu-Ping, Ko; Hsiu-Chien, Chan; Jikun, Li; Yingying, Zheng; ChunHsiang, Huang; Feifei, Ren; Chun-Chi, Chen; Zhen, Zhu; Melina, Galizzi; Zhu-Hong, Li; Carlos A, Rodrigues-Poveda; Dolores, Gonzalez-Pacanowska; Phercyles, Veiga-Santos; Tecia Maria Ulisses; de Carvalho; Wanderley, de Souza; Julio A, Urbina; Andrew H-J, Wang; Roberto, Docampo; Kai, Li; YiLiang, Liu; Eric, Oldfield; Rey-Ting, Guo ; Squalene Synthase As a Target for Chagas Disease Therapeutics, PLoS Pathogens, 2014, 10(5): 1178-1191.  ( 共同一作 )

（2）Guizhi Liua, Qian Li, Na Shang , Jian-Wen Huang, Tzu-Ping Koe, Weidong Liub, Yingying Zheng b, Xu Hanb, Yun Chenf , Chun-Chi Chenb, Jian Jinf, Rey-Ting Guo.Functional and structural analyses of a 1,4- -endoglucanase from Ganoderma lucidum,Enzyme and Microbial Technology,2016,86:67–74 ( 共同一作 ).

（3）Zhongxia Xu, Weidong Liu,Chun-Chi Chen,Qian Li,Jian-Wen Huang,Tzu-Ping Ko,Guizhi Liu, Wenting Liu,Wei Peng,Ya-Shan Cheng,Yun Chen,Jian Jin, Huazhong Li,Yingying Zheng,and Rey-Ting Guo.Enhanced α‑Zearalenol Hydrolyzing Activity of a Mycoestrogen

Detoxifying Lactonase by Structure-Based Engineering,ACS Catalysis,2016, 6:7657−7663.

（4）Gerlis von Haugwitz; Xu Han; Lara Pfaff; Qian Li; Hongli Wei; Jian Gao; Karen Methling; Yufei Ao; Yannik Brack; Jan Mican; Christian G. Feiler; Manfred S. Weiss; David Bednar; Gottfried J. Palm; Michael Lalk; Michael Lammers; Jiri Damborsky; Gert Weber; Weidong Liu; Uwe T.

Bornscheuer; Ren Wei ; Structural Insights into (Tere)phthalate-Ester Hydrolysis by a Carboxylesterase and Its Role in Promoting PET Depolymerization, ACS Catalysis, 2022, 12(24): 15259-15270 .

（5）Hongliu Zhang; Xi Chen; Tong Lv; Qian Li; Weidong Liu; Jinhui Feng; Xiangtao Liu; Peiyuan Yao; Qiaqing Wu; Dunming Zhu ; Engineering a Carbonyl Reductase to Simultaneously Increase

Activity Toward Bulky Ketone and Isopropanol for Dynamic Kinetic Asymmetric Reduction via Enzymatic Hydrogen Transfer, ACS Catalysis, 2023, 13(1): 9960-9968 .

（6）Zhu, Yueming; Chen, Peng; Dong, Qianzhen; Li, Qian; Liu, Dechuan; Liu, Tao; Liu, Weidong; Sun, Yuanxia ; Protein engineering of transaminase facilitating enzyme cascade reaction for the biosynthesis of azasugars, ISCIENCE, 2024, 27(3): 1-14.