[1] P. Zhang#, Z. Tian, C. Li, R. Meng, B. Zhang, X. Liu, J. Li, G. Qu, N. J. Turner, B. Yuan*, H. Fu*, Z. Sun*, Biocatalytic Atroposelective Synthesis of Axially Chiral Styrenes via Dynamic Kinetic Resolution, Angew. Chem. Int. Ed., 2026, 65, e21538.

[2] P. Zhang#, B. Yuan#, J. Li, C. Li, J. Guo, B. Zhang, G. Qu, H. Su, N. J. Turner, Z. Sun*, Biocatalytic Desymmetrization for the Atroposelective Synthesis of Axially Chiral Biaryls Using an Engineered Imine Reductase, Angew. Chem. Int. Ed., 2025, 64, e202416569.

[3] J. Li#, B. Yuan#, C. Li, Z. Zhao, J. Guo, P. Zhang, G. Qu, Z. Sun*, Stereoselective Synthesis of Oxetanes Catalyzed by an Engineered Halohydrin Dehalogenase, Angew. Chem. Int. Ed., 2024, 63, e202411326.

[4] Z. Zhao#, J. Li, C. Li, G. Qu, B. Yuan*, L. Chen*, Z. Sun*, Engineering Limonene Epoxide Hydrolases for the Enantiocomplementary Synthesis of Chiral 1,3-Diols and Oxetanes, ACS Catal., 2025, 15, 9201–9209.

[5] B. Yuan, D. Mahor, Q. Fei, R. Wever, M. Alcalde, W. Zhang*, F. Hollmann*, Water-Soluble Anthraquinone Photocatalysts Enable Methanol-Driven Enzymatic Halogenation and Hydroxylation Reactions, ACS Catal., 2020, 10, 8277.

[6] B. Yuan*, D. Yang, G. Qu, N. J. Turner*, Z. Sun*, Biocatalytic Reductive Aminations with NAD(P)H-Dependent Enzymes: Enzyme Discovery, Engineering and Synthetic Applications, Chem. Soc. Rev., 2024, 53, 227.

[7] J. Zhou#, X. Wang, Y. Wang, P. Zhang, H. Wang, B. Yuan*, Z. Sun*, Engineering Ene-Reductases for the Chemoenzymatic Synthesis of a Sacubitril Intermediate and Its Derivatives, Org. Lett., 2026, 28, 5377.

[8] P. Liu#, Z. Kang, P. Xie, Z. Zhu, B. Yuan*, Z. Sun*, Chemoenzymatic Cascades by Enzyme Immobilization with TEMPO-Appended Metal-Organic Framework for Ethylene Glycol Oxidation, Mol. Catal., 2025, 584, 115276.

[9] J. Shi#, B. Yuan*, H. Yang*, Z. Sun*, Recent Advances on Protein Engineering for Improved Stability, BioDesign Research, 2025, 7, 100005.

[10] J. Luo#, C. Li, M. Ye, P. Zhang, G. Qu, Z. Cai, C. Wang, B. Yuan*, Z. Sun*, 含吡咯及吲哚基团的N–N轴手性化合物的酶催化合成, 生物工程学报, 2025, 41, 2088–2100.

[11] P. Zhang#, B. Yuan*, Z. Sun*, Biocatalytic Strategies for the Synthesis of Atropisomers, Chem. Eur. J., 2025, 31, e03010.

[12] P. Xie, J. Lan, J. Zhou, Z. Hu, J. Cui, G. Qu, B. Yuan*, Z. Sun*, Co-Immobilization of Amine Dehydrogenase and Glucose Dehydrogenase for the Biosynthesis of (S)-2-Aminobutan-1-ol in Continuous Flow, Bioresour. Bioprocess., 2024, 11, 70.

[13] M. Ye, C. Li, D. Xiao, G. Qu, B. Yuan*, Z. Sun*, Atroposelective Synthesis of Aldehydes via Alcohol Dehydrogenase-Catalyzed Stereodivergent Desymmetrization, JACS Au, 2024, 4, 411.

[14] L. Chen, G. Qu, Z. Cai, B. Yuan*, Z. Sun*, Synthesis of a Sacubitril Precursor by Construction of One-Pot Chemoenzymatic Cascades, Catal. Sci. Technol., 2024, 14, 2817–2824.

[15] X. Li, J. Wang, W. Su, C. Li, G. Qu, B. Yuan*, Z. Sun*, Characterization and Engineering of Cephalosporin C Acylases to Produce 7-Aminocephalosporanic Acid, Mol. Catal., 2023, 550, 113595.

[16] Y. Li, C. Bao, Z. Sun, W. Zhang*, B. Yuan*, Comparison Between Chemoenzymatic and Bienzymatic Cascades Leading to Morita–Baylis–Hillman Adducts, ChemCatChem, 2023, 15, e202201621.

[17] W. Huang, S. Huang, Z. Sun, W. Zhang, Z. Zeng*, B. Yuan*, Chemoenzymatic Synthesis of Sterically Hindered Biaryls by Suzuki Coupling and Vanadium Chloroperoxidase-Catalyzed Halogenations, ChemBioChem, 2023, 24, e202200610.

[18] S. Song#, Y. Jiang#, R. Chen, W. Su, W. Liang, D. Yang, J. Li, W. Zhang, S. Gao, B. Yuan*, G. Qu*, Z. Sun*, Whole-Cell Biotransformation of Penicillin G by a Three-Enzyme Co-Expression System with Engineered Deacetoxycephalosporin C Synthase, ChemBioChem, 2022, 23, e202200179.

[19] T. Cui#, B. Yuan#, H. Guo, H. Tian, W. Wang, Y. Ma, C. Li, Q. Fei*, Enhanced Lignin Biodegradation by Consortium of White Rot Fungi: Microbial Synergistic Effects and Product Mapping, Biotechnol. Biofuels, 2021, 14, 162.

[20] B. Yuan, D. Debecker, X. Wu, J. Xiao, Q. Fei*, N. J. Turner*, One-Pot Chemoenzymatic Deracemisation of Secondary Alcohols Employing Variants of Galactose Oxidase and Transfer Hydrogenation, ChemCatChem, 2020, 12, 6191.

[21] B. Yuan, F. Escalettes, N. J. Turner*, Practical Methods for Biocatalysis and Biotransformations 2, Chapter 6.2 & Chapter 6.3, John Wiley & Sons, Ltd., 2012.

[22] B. Yuan, A. Page, C. P. Worrall, F. Escalettes, S. C. Willies, J. J. W. McDouall, N. J. Turner*, J. Clayden*, Biocatalytic Desymmetrization of an Atropisomer with Both an Enantioselective Oxidase and Ketoreductases, Angew. Chem. Int. Ed., 2010, 49, 7010.

[23] X. Huang#, M. Xia, H. Dong, X. Ren, G. Fu, B. Yuan, A. Jiang, L. Chen, Z. Sun, S. Qian*, Combinatorial Optimization of Cellular Regulation and Fermentation for High-Efficiency Expression of Cephalosporin C Acylase in Escherichia coli, Process Biochem., 2026, 163, 16–26.

[24] X. Liu#, B. Liu, L. Qi, X. Feng, C. Deng, L. Wang, B. Yuan, S. Li, Y. Zhao, H. Wu*, Stepwise Engineering of AmpR-Based Whole-Cell Biosensors for Broad-Spectrum Detection and High-Throughput Screening of β-Lactam Compounds, Biosens. Bioelectron., 2026, 118686.

[25] X. Ren#, Z. Yang, S. Chen, C. Pu, H. Wang, J. Li, Q. Cao, X. Huang, G. Fu, B. Yuan, J. Luo, Z. Sun, H. Dong, D. Zhang*, Systematic Mining and Engineering of Signal Peptides to Achieve Efficient Secretion of Cephalosporin C Acylase in Escherichia coli, Synth. Syst. Biotechnol., 2026, 13, 508–516.

[26] S. Liu#, J. Wang, B. Yuan, X. Meng, G. Qu, Z. Sun*, Integration of Computational Tools for Rational Design of (R)-ω-Transaminases with Enhanced Asymmetric Catalysis, Mol. Catal., 2025, 579, 115078.

[27] W. Su#, G. Qu#, H. Wu, J. Li, B. Yuan, Z. Sun*, Biocatalytic Synthesis of 7-Aminodesacetoxycephalosporanic Acid with Engineered E. coli Dual Cells and Immobilized Enzymes, ACS Sustainable Chem. Eng., 2025, 13, 10316–10325.

[28] B. Zhang#, C. Li, P. Zhang, J. Li, B. Yuan, G. Qu, M. T. Reetz, Z. Sun*, In Silico Prediction of a Multimutational Stereoselective Alcohol Dehydrogenase, ACS Catal., 2025, 15, 16633–16642.

[29] X. Zhao#, H. Guo, H. Huang, M. Zheng, Z. Zhang, J. Li, C. Li, B. Yuan, C. Pan, Z. Sun*, Contamination and Biotransformation of Deoxynivalenol (DON) in Common Commercial Foods: Current Status, Challenges and Future Perspectives, Green Synth. Catal., 2025, DOI: 10.1016/j.gresc.2025.04.008.

[30] Z. Zhu#, Z. Qin, B. Yuan, Z. Cai, G. Qu, Z. Sun*, Enhanced Production of Leucine–Leucine Dipeptide by Whole-Cell Catalysis, J. Agric. Food Chem., 2025, 73, 9807–9816.

[31] Z. Qin, B. Yuan, G. Qu*, Z. Sun*, Rational Enzyme Design by Reducing the Number of Hotspots and Library Size, Chem. Commun., 2024, 60, 10451–10463.

[32] Q. Wang, C. Li, B. Yuan, A. Yu, G. Qu*, Z. Sun*, Engineering the Activity of a Newly Identified Arylalkylamine N-Acetyltransferase in the Acetylation of 5-Hydroxytryptamine, ChemBioChem, 2024, e202400069.

[33] Y. Ren, Z. Qin, C. Li, B. Yuan, Y. Yang, G. Qu*, Z. Sun*, Engineering the Activity and Thermostability of a Carboxylic Acid Reductase in the Conversion of Vanillic Acid to Vanillin, J. Biotechnol., 2024, 386, 19–27.

[34] C. Paul, U. Hanefeld, F. Hollmann*, G. Qu, B. Yuan, Z. Sun, Enzyme Engineering for Biocatalysis, Mol. Catal., 2024, 555, 113874.

[35] X. Li, C. Li, G. Qu, B. Yuan, Z. Sun*, Engineering of a Baeyer–Villiger Monooxygenase to Improve Substrate Scope, Stereoselectivity and Regioselectivity, ChemBioChem, 2024, 25, e202400328.

[36] X. Sang, F. Tong, Z. Zeng, M. Wu, B. Yuan, Z. Sun, X. Sheng, G. Qu, M. Alcalde, F. Hollmann, W. Zhang, A Biocatalytic Platform for the Synthesis of Enantiopure Propargylic Alcohols and Amines, Org. Lett., 2022, 24, 4252–4257.

[37] H. Ming, B. Yuan, G. Qu*, Z. Sun*, Engineering the Activity of Amine Dehydrogenase in the Asymmetric Reductive Amination of Hydroxyl Ketones, Catal. Sci. Technol., 2022, 12, 5952.

[38] Y. Li, B. Yuan, Z. Sun, W. Zhang*, C–H Bond Functionalization Reactions Enabled by Photobiocatalytic Cascades, Green Synth. Catal., 2021, 2, 267–274.

[39] S. Staniland, B. Yuan, N. Gimenez-Agullo, T. Marcelli, S. C. Willies, D. M. Grainger, N. J. Turner*, J. Clayden*, Enzymatic Desymmetrising Redox Reactions for the Asymmetric Synthesis of Biaryl Atropisomers, Chem. Eur. J., 2014, 20, 13084.

[40] G. Qu, B. Yuan, Z. Sun, 工业蛋白质理性设计与应用, 生物工程学报, 2022, 38, 4068–4080.

[41] Y. Shang, B. Yuan, Q. Fei, 生物催化轴手性化合物的不对称合成进展, 高校化学工程学报, 2021, 35, 14.

[42] W. Zhang, B. Yuan, G. Qu, Z. Sun, 光促酶催化反应设计及生物合成应用, 生物学杂志, 2021, 38, 1.

申请及授权发明专利

1. 袁波, 孙周通, 张鹏鹏, 陈龙, 罗佳慧，一种沙库巴曲中间体的合成方法，2023112695532, 2023.9.28；

2. 袁波, 孙周通, 李湘莹, 苏文成，一种头孢菌素C酰化酶的人工合成及其突变体应用，202210655746.0, 2022.6.10；

3. 袁波,孙周通, 李湘莹, 苏文成，一种头孢菌素C酰化酶突变体及其应用，202210655745.6, 2022.6.10；

4. 袁波,宋世怡, 李湘莹, 苏文成, 蒋迎迎, 曲戈, 孙周通, 张武元, 扩环酶及其突变体在生产G-7-ADCA中的应用，CN202110676893.1, 2021.6.18；

5. 孙周通, 袁波, 苏文成, 李湘莹，一种头孢菌素C酰化酶催化的酰化反应及其应用，202210655575.1， 2022.6.10；

6. 孙周通, 袁波, 苏文成, 李湘莹, 李金成，头孢菌素C酰化酶突变体及其在头孢菌素母核合成中的应用，202210655545.0，2022.6.10；

7. 孙周通, 袁波, 李军宽, 曲戈，一种卤代醇脱卤酶突变体及手性γ-氨基醇的合成方法，CN202410887460.4;

8. 孙周通, 袁波, 李军宽, 曲戈，一种环氧水解酶催化氧杂环丁烷水解的新方法，CN202410968017.X;

9. 孙周通, 袁波, 刘玲怡, 李湘迎, 曲戈，一种青霉素酰化酶基因及合成β-内酰胺类抗生素的方法，CN202411170627.1；

10. 孙周通, 袁波, 兰金, 曲戈，一种具有底物特异性的头孢菌素 C 酰化酶突变体及其应用，CN202411292458.9;

11. 孙周通, 袁波, 梁爽, 曲戈，一种头孢菌素 C 酰化酶突变体，CN202411374139.2；

12. 孙周通, 袁波, 李聪聪, 曲戈，一种扩环酶突变体及其在制备头孢烷酸类化合物中的应用，CN202411544509.2；

13. 孙周通, 曲戈, 苏文成, 仓天娇, 袁波, 李聪聪, 王晴，一种扩环酶突变体及其在合成 G-7-ADCA 中的应用，CN202410968196.7;

14. 孙周通, 苏文成, 曲戈, 袁波，一种脱乙酰头孢菌素 C 生产菌及其制备方法与应用，CN202411773160.X；

15. 孙周通, 曲戈, 朱子铭, 袁波，一种亮氨酸二肽化合物的合成方法，CN202411638154.3；

16. 孙周通, 曲戈, 李金成, 王晴, 袁波，一种合成褪黑素的基因工程菌及其应用，CN202411378457.6；

17. 孙周通, 李旭, 曲戈, 袁波，一种（S）-3-羟基四氢呋喃的生物酶合成方法，CN202410762691.2；

18. 孙周通, 杨大猛, 李湘莹, 苏文成, 蒋迎迎, 曲戈, 张武元, 袁波，一种生产7-氨基去乙酰氧基头孢烷酸的方法，202111097082.2