副研究员/高级工程师
郑迎迎

郑迎迎


  • 职  称:高级研发人员III级(副研究员)
  • 学  历:博士研究生
  • 通讯地址:天津空港经济区西七道32号
  • 电  话:022-24828704
  • 邮政编码:300308
  • 电子邮件:zheng_yy@tib.cas.cn
  • 部  门:总体研究部(功能大分子生物合成中心)

简历

1、教育经历

2000.9-2004.7,南京理工大学,高分子材料与工程,学士

2004.9-2006.7,南京理工大学,生物化工,硕士

2006.9-2010.7,中国科学院微生物研究所,微生物学,博士

2007.10-2008.9,德国不莱梅国际大学,生物化学,联合培养  

2、工作经历

2010.9-2014.4,中国科学院天津工业生物技术研究所,助理研究员

2014.5至今,中国科学院天津工业生物技术研究所,副研究员

研究方向

利用蛋白质晶体结构解析的技术手段研究蛋白结构功能关系,主要研究对象为:工业酶、抗生素合成途径中关键蛋白、嗜热菌代谢途径中关键蛋白。

代表成果

  1、论文

  [1] ZHENG Yingying,XUE Yanfen,ZHANG Yueling,ZHOU Cheng,Ulrich Schwaneberg,MA Yanhe. Cloning,expression,and characterization of a thermostable glucoamylase from Thermoanaerobacter tengcongensis MB4 [J]. Applied Microbiology and Biotechnology, 2010,87(1):225-233

  [2] ZHENG Yingying,HUANG Chun-Hsiang,LIU Wenting,KO Tzu-Ping,XUE Yanfen,ZHOU Cheng,GUO Rey-Ting,MA Yanhe. Crystal structure and substrate-binding mode of a novel pectate lyase from Alkaliphilic Bacillus sp. N16-5 [J]. Biochemical and Biophysical Research Communications,2012,420(2):269-274

  [3] HU Yumei,JIAS, REN Feifei, HUANG Chun-Hsiang, KO Tzu-Ping, D. A. Mitchell, GUO Rey-Ting and ZHENG Yingying*. Crystallization and preliminary X-ray diffraction analysis of YisP protein from Bacillus subtilis subsp. subtilis strain 168 [J].Acta Cryst F., 2013,69: 77-79 

  [4] RAO Lang,XUE Yanfen, ZHENG Yingying,LV Jianren,MA Yanhe. A Novel Alkaliphilic Bacillus Esterase Belongs to the 13th Bacterial Lipolytic Enzyme Family [J]. PLOS ONE,2013,8(4):e60645

  [5] Xu Jianyong, REN Feifei, HUANG Chun-Hsiang, ZHENG Yingying, ZHEN Jie, SUN Hong,KO Tzu-Ping, HE Miao, CHEN Chun-Chi, CHAN Hsiu-Chien, GUO Rey-Ting, SONG Hui and MA Yanhe. Functional and structural studies of pullulanase from Anoxybacillus sp. LM18-11 [J]. Proteins,DOI: 10.1002/prot.24498

  [6] SHANG Na,LI Qian,KO Tzu-Ping,CHAN Hsiu-Chien,ZHENG Yingying,HUANG Chun-Hsiang,REN Feifei,CHEN Chun-Chi,ZHU Zhen,Galizzi M,Rodrigues-Poveda CA,Gonzalez-Pacanowska D,Veiga-Santos P,de Carvalho TM,de Souza W,Urbina JA,Wang AH,Docampo R,Oldfield E,GUO Rey-Ting. Squalene synthase as a target for chagas disease therapeutics [J].PLoS Pathog,2014,10(5) :e1004114

  [7] CHAN Hsiu-Chien,FENG Xinxin,KO Tzu-Ping,HUANG Chun-Hsiang,HU Yumei,ZHENG Yingying,Bogue S,Nakano C,Hoshino T,ZHANG Lilan,LV Pin,LIU Wenting,Crick DC,Oldfield E,GUO Rey-Ting. Structure and inhibition of tuberculosinol synthase and decaprenyl diphosphate synthase from Mycobacterium tuberculosis [J]. J Am Chem Soc,2014,136(7):2892-6

  [8] HUANG Chun-Hsiang,KO Tzu-Ping,CHEN Chun-Chi,ZHENG Yingying,CHAN Hsiu-Chien,PANG Xuefei,Wiegel J,SHAO Weilan,GUO Rey-Ting. The substrate/product-binding modes of a novel GH120 β-xylosidase (XylC) from Thermoanaerobacterium saccharolyticum JW/SL-YS485 [J]. Biochem J,2012,448(3) :401-7  

  2专著中析出文献

[1] 郑迎迎,郭瑞庭. 植酸酶的性质、应用和三维结构[C]. 中国科学院生命科学与生物技术局. 2011工业生物技术发展报告. 北京:科学出版社,2011:70-83   

  3、申请专利

[1] 马延和郑迎迎薛燕芬. 一种葡萄糖淀粉酶及其编码基因与应用:中国,200910091269[P].2009-8-14