副研究员/高级工程师
郑小梅

郑小梅


  • 职  称:副研究员
  • 学  历:博士研究生
  • 导师类别:硕士生导师
  • 通讯地址:天津空港经济区西七道32号
  • 电  话:022-84861943
  • 邮政编码:300308
  • 电子邮件:zheng_xm@tib.cas.cn
  • 部  门:系统与合成生物技术研究组

简历

1、教育经历

2002/09-2006/06 临沂大学,生物科学,学士

2006/09-2009/06 中国农业科学院,生物化学与分子生物学,硕士

2006/09-2012/06 中国农业科学院,生物化学与分子生物学,博士

2、工作经历

2012/09-2018/11 中国科学院天津工业生物技术研究所,助理研究员

2014/07-2014/12 德国柏林工业大学,中国科学院青年访问学者

2018/11-至今  中国科学院天津工业生物技术研究所,副研究员

研究方向

致力于黑曲霉等工业微生物的系统与合成生物学研究,重点开发系统生物学技术与高通量基因组编辑技术,整合多组学数据,解析黑曲霉等工业微生物的独特分子机制,辅以计算机设计开发创建新型细胞工厂,实现工业化菌株的个性化定制,推动传统发酵行业的升级换代与绿色发展。在Microb BiotechnolACS Synth BiolBiotechnol JMicrob Cell FactBiotechnol Biofuels等杂志上发表SCI论文20篇,申请发明专利8,其中授权2项。

获奖及荣誉

2018/10中国微生物协会学术年会优秀报告奖

2019/10中国微生物协会学术年会优秀报告奖

2019/10中国粮油协会科技进步特等奖(第四)

代表成果

1Zheng X, Cairns TC, Ni X, Zhang L, Zhai H, Meyer V, Zheng P, Sun J. Comprehensively dissecting the hub regulation of PkaC on high-productivity and pellet macromorphology in citric acid producing Aspergillus niger. Microb Biotechnol.2022 Feb 25. doi: 10.1111/1751-7915.14020.

2Zheng X, Zheng P, Sun J. CRISPR/Cas-based genome editing in Aspergillus niger. Sheng Wu Gong Cheng Xue Bao. 2021 Mar 25;37(3):980-990.

3Zhang L#, Zheng X#, Cairns TC, Zhang Z, Wang D, Zheng P, Sun J. Disruption or reduced expression of the orotidine-5'-decarboxylase gene pyrG increases citric acid production: a new discovery during recyclable genome editing in Aspergillus niger. Microb Cell Fact. 2020 Mar 24;19(1):76.

4Zheng X, Zheng P, Zhang K, Cairns TC, Meyer V, Sun J, Ma Y. 5S rRNA Promoter for Guide RNA Expression Enabled Highly Efficient CRISPR/Cas9 Genome Editing in Aspergillus niger. ACS Synth Biol. 2019 Jul 19;8(7):1568-1574. 

5Zheng X, Yu J, Cairns TC, Zhang L, Zhang Z, Zhang Q, Zheng P, Sun J, Ma Y. Comprehensive Improvement of Sample Preparation Methodologies Facilitates Dynamic Metabolomics of Aspergillus niger. Biotechnol J. 2019 Mar;14(3):e1800315.

6Zheng X, Zheng P, Sun J. Systems biology for industrial biotechnology. Sheng Wu Gong Cheng Xue Bao. 2019 Oct 25;35(10):1955-1973.

7 Tong Z#, Zheng X#, Tong Y, Shi YC, Sun J. Systems metabolic engineering for citric acid production by Aspergillus niger in the post-genomic era. Microb Cell Fact. 2019 Feb 4;18(1):28.

8Zheng X, Zheng P, Sun J, Zhang K, Ma Y. Heterologous and endogenous U6 snRNA promoters enable CRISPR/Cas9 mediated genome editing in Aspergillus niger. Fungal Biol Biotechnol. 2018 Feb 8;5:2.

9Zhang Q#, Zheng X#, Wang Y, Yu J, Zhang Z, Dele-Osibanjo T, Zheng P, Sun J, Jia S, Ma Y. Comprehensive optimization of the metabolomic methodology for metabolite profiling of Corynebacterium glutamicum. Appl Microbiol Biotechnol. 2018 Jun 6.

10Cairns TC, Zheng X, Feurstein C, Zheng P, Sun J, Meyer V. A Library of Aspergillus niger Chassis strains for morphology engineering connects strain fitness and filamentous growth with submerged macromorphology. Front Bioeng Biotechnol. 2022 Jan 17;9:820088.

11Cairns TC, Zheng X, Zheng P, Sun J, Meyer V. Turning Inside Out: Filamentous Fungal Secretion and Its Applications in Biotechnology, Agriculture, and the Clinic. J Fungi (Basel). 2021 Jul 2;7(7):535.

12 Cairns TC, Zheng X, Zheng P, Sun J, Meyer V. Moulding the mould: understanding and reprogramming filamentous fungal growth and morphogenesis for next generation cell factories. Biotechnol Biofuels. 2019 Apr 2;12:77.

13 Cairns TC#, Feurstein C#, Zheng X, Zheng P, Sun J, Meyer V. A quantitative image analysis pipeline for the characterization of filamentous fungal morphologies as a tool to uncover targets for morphology engineering: a case study using aplD in Aspergillus niger. Biotechnol Biofuels. 2019 Jun 15;12:149.

14 Wang X, Li Q, Sun C, Cai Z, Zheng X, Guo X, Ni X, Zhou W, Guo Y, Zheng P, Chen N, Sun J, Li Y, Ma Y. GREACE-assisted adaptive laboratory evolution in endpoint fermentation broth enhances lysine production by Escherichia coli. Microb Cell Fact. 2019 Jun 11;18(1):106.

15 Wang Y, Liu Y, Liu J, Guo Y, Fan L, Ni X, Zheng X, Wang M, Zheng P, Sun J, Ma Y. MACBETH: Multiplex automated Corynebacterium glutamicum base editing method. Metab Eng. 2018 May; 47:200-210