李键煚----中国科学院天津工业生物技术研究所

人才队伍

副研究员/高级工程师

李键煚

职　　称：高级工程师
学　　历：硕士研究生
通讯地址：天津市空港经济区西七道32号
电　　话：022-84861965
邮政编码：300308
电子邮件：li_jj@tib.cas.cn
部　　门：生物催化反应机理及应用研究组

简历

2023.10-至今，中国科学院天津工业生物技术研究所，高级工程师

2014.04-2023.10，中国科学院天津工业生物技术研究所，助理研究员

2009.11-2014.04，中国科学院天津工业生物技术研究所，研究实习员

2008.06-2009.04，天津药明康德新药开发有限公司，合成部职员

2005.09-2008.06，河北师范大学，化学与材料科学学院，有机化学专业，硕士

研究方向

生物催化反应工艺设计及优化，酶固定化

获奖及荣誉

代表成果

在ACS Catal., Org. Lett., ChemCatChem等期刊发表学术论文20余篇，申请专利10件，已授权专利6件。

Jianjiong Li,^# Shanshan Yu,^# Yingang Wang, Peiyuan Yao,* Qiaqing Wu,* Dunming Zhu*, Simultaneous Preparation of (S)-2-Aminobutane and d-α-Amino Acids via Biocatalytic Transamination at High Substrate Concentration, Org. Process Res. Dev., 2022, 26, 2013-2020.
Linsong Yang,^# Jianjiong Li,^# Zefei Xu, Peiyuan Yao,* Qiaqing Wu, Dunming Zhu,* Yanhe Ma*, Asymmetric Synthesis of Fused-Ring Tetrahydroisoquinolines and Tetrahydro-β-carbolines from 2‑Arylethylamines via a Chemoenzymatic Approach, Org. Lett., 2022, 24, 6531-6536.
Jiacheng Li, ^# Jianjiong Li, ^# Yunfeng Cui, Min Wang, Jinhui Feng, Peiyuan Yao,* Qiaqing Wu, Dunming Zhu*, Asymmetric Synthesis of Both Enantiomers of Dimethyl 2-Methylsuccinate by the Ene-Reductase-Catalyzed Reduction at High Substrate Concentration, Catalysts, 2022, 12, 1133.
Jianjiong Li, Xi Chen, Yunfeng Cui, Weidong Liu, Jinhui Feng, Qiaqing Wu,^⁎ Dunming Zhu^⁎, Enzymatic synthesis of d-alanine from a renewable starting material by co-immobilized dehydrogenases，Process Biochemistry, 2018, 66, 126-132．
Peiyuan Yao,^# Jianjiong Li,^# Jing Yuan, Chao Han, Xiangtao Liu, Jinhui Feng, Qiaqing Wu,* Dunming Zhu*, Enzymatic Synthesis of a Key Intermediate for Rosuvastatin by Nitrilase-Catalyzed Hydrolysis of Ethyl (R)-4-Cyano-3-hydroxybutyate at High Substrate Concentration, ChemCatChem, 2015, 7, 271-275.
Dunming Zhu, Jianjiong Li, Qiaqing Wu, Marine enzymes for biocatalysis (Stereoselective synthesis using marine enzymes), Woodhead publishing, 2013.