1. 教育经历

2012.09-2015.03 天津科技大学轻工技术与工程专业

2. 工作经历

2015.04-至今 中国科学院天津工业生物技术研究所，依次任研究实习员、助理研究员、工程师、高级工程师

主要从事代谢工程、分子生药学等前沿交叉学科研究，具体包括功能基因鉴定平台的开发及应用、高效仿生合成细胞创建、亚细胞区室工程、精确发酵体系创建及吨级放大等。目前以酿酒酵母为底盘微生物创建了系列高值天然产物的仿生合成细胞，其中KH617（I类抗癌新等产品系已实现技术转让。

1. Liping Xu, Dong Wang, Jing chen, Bo Li, Qingyan Li, Pingping Liu, Ying Qin, Changhao Bi, Zhubo Dai*, Feiyu Fan*, Xueli Zhang*, Metabolic engineering of Saccharomyces cerevisiae for gram-scale diosgenin production, Metabolic Engineering, 2022, 70：115–128.

2. Rongsheng Li, Kou Wang, Dong Wang, Liping Xu, Yusong Shi, Zhubo Dai* and Xueli Zhang*, Production plant volatile terpenoids (Rose Oil) by yeast cell factories, Green Chemistry, 2021, 23: 5088-5096.

3. Weixian Li, Xiaohui Ma, Guodong Li, Aili Zhang, Dong Wang, Feiyu Fan, Xiaolin Ma, Xueli zhang*, Zhubo Dai* and Zigang Qian*, De novo biosynthesis of the oleanane-type triterpenoids of tunicosaponins in yeast, ACS Synthetic Biology, 2021, 10(8): 1874–1881.

4.  Yusong Shi, Dong Wang, Rongsheng Li, Luqi Huang, Zhubo Dai* and Xueli Zhang*, Engineering yeast subcellular compartments for increased production of the lipophilic natural products ginsenosides, Metabolic Engineering, 2021, 67: 104-111.

5. Dong Wang, Jinhe Wang, Yusong Shi, Rongsheng Li, Feiyu Fan, Yin Huang, Weixian Li, Ning Chen, Luqi Huang, Zhubo Dai* and Xueli Zhang*, Elucidation of the complete biosynthetic pathway of the main triterpene glycosylation products of Panax notoginseng using a synthetic biology platform, Metabolic Engineering, 2020, 61:131-140.

6. Zhubo Dai, Yun Liu, Zhoutong Sun, Dong Wang, Ge Qu, Lili Zhang, Shoulian Li, Xiaolin Ma, Feiyu Fan, Xueli Zhang*, Identification of a novel cytochrome P450 enzyme that catalyzes the C-2α hydroxylation of pentacyclic triterpenoids and its application in yeast cell factories, Metabolic Engineering, 2019,51:70-78.

7. Jiajian Huang, Wenlong Zha, Tianyue An，Yin Huang, Dong Wang,Tianyue An, Hua Dong, Rongmin Yu, Lixin Duan, Xueli Zhang, Reuben J. Peters*, Zhubo Dai*, Jiachen Zi*. Identification of RoCYP01 (CYP716A155) enables construction of engineered yeast for high-yield production of betulinic acid, Applied Microbiology and Biotechnology, 2019, 103(17):7029-7039.